Reaction Details |
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Target | Tyrosine-protein kinase Fgr |
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Ligand | BDBM50392791 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_853155 (CHEMBL2154704) |
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IC50 | 2.2±n/a nM |
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Citation | Wang, T; Lamb, ML; Block, MH; Davies, AM; Han, Y; Hoffmann, E; Ioannidis, S; Josey, JA; Liu, ZY; Lyne, PD; MacIntyre, T; Mohr, PJ; Omer, CA; Sjögren, T; Thress, K; Wang, B; Wang, H; Yu, D; Zhang, HJ Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett3:705-709 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Fgr |
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Name: | Tyrosine-protein kinase Fgr |
Synonyms: | FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr |
Type: | protein |
Mol. Mass.: | 59469.88 |
Organism: | Homo sapiens (Human) |
Description: | P09769 |
Residue: | 529 |
Sequence: | MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
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BDBM50392791 |
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n/a |
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Name | BDBM50392791 |
Synonyms: | CHEMBL2151321 | US8486966, 1 |
Type | Small organic molecule |
Emp. Form. | C19H20FN7O |
Mol. Mass. | 381.4068 |
SMILES | CC(C)Oc1cc(n[nH]1)-n1cnc2ccc(N[C@@H](C)c3ccc(F)cn3)nc12 |r| |
Structure |
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