| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50392919 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_853422 (CHEMBL2155280) |
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| IC50 | 0.4±n/a nM |
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| Citation |  Yu, J; Liu, H; Xia, G; Liu, L; Xu, Z; Chen, Q; Ma, C; Sun, X; Xu, J; Li, H; Li, P; Shi, Y; Xiong, B; Liu, X; Shen, J Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitors. ACS Med Chem Lett3:793-798 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50392919 |
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| n/a |
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| Name | BDBM50392919 |
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| Synonyms: | CHEMBL2152217 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H33ClN2O3S |
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| Mol. Mass. | 453.038 |
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| SMILES | Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@@H](C1)C(=O)N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C |r,THB:19:20:27:23.24| |
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| Structure | 
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