Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50392924 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_853422 (CHEMBL2155280) | ||
IC50 | 0.1±n/a nM | ||
Citation | Yu, J; Liu, H; Xia, G; Liu, L; Xu, Z; Chen, Q; Ma, C; Sun, X; Xu, J; Li, H; Li, P; Shi, Y; Xiong, B; Liu, X; Shen, J Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitors. ACS Med Chem Lett3:793-798 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50392924 | |||
n/a | |||
Name | BDBM50392924 | ||
Synonyms: | CHEMBL2152223 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H31ClN2O4S | ||
Mol. Mass. | 467.021 | ||
SMILES | Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@]1(C)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:15.17,20.21,wD:15.18,27.30,TLB:19:20:30.26.27:24.23.22,19:20:22:30.27.29,28:27:20.25.24:22,THB:26:25:22:30.27.29,26:27:20.25.24:22,29:27:20:24.23.22,29:23:20:30.26.27,28:27:20:24.23.22,(11.34,-28.78,;11.34,-27.24,;10,-26.47,;8.67,-27.24,;10.01,-24.93,;11.34,-24.16,;12.67,-24.92,;12.68,-26.47,;14.01,-27.24,;14.77,-28.57,;13.24,-28.56,;15.34,-26.47,;15.5,-24.92,;17.01,-24.6,;17.78,-25.94,;16.74,-27.08,;17.83,-28.17,;16.35,-28.57,;15.24,-29.65,;17.43,-29.66,;18.92,-29.26,;20.12,-27.98,;20.11,-26.5,;21.46,-26.02,;20.42,-27.25,;20.42,-28.84,;21.83,-29.4,;22.84,-28.13,;24.38,-28.07,;22.85,-26.6,;21.45,-28.47,)| | ||
Structure |