| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
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| Ligand | BDBM50172473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_853436 (CHEMBL2155294) |
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| IC50 | 1300±n/a nM |
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| Citation |  Windsor, MA; Hermanson, DJ; Kingsley, PJ; Xu, S; Crews, BC; Ho, W; Keenan, CM; Banerjee, S; Sharkey, KA; Marnett, LJ Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes. ACS Med Chem Lett3:759-763 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 |
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| Name: | Prostaglandin G/H synthase 2 |
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| Synonyms: | Cox-2 | Cox2 | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2) | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGH2_MOUSE | PGHS-2 | PHS II | Pghs-b | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2 | TIS10 protein | Tis10 |
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| Type: | Protein |
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| Mol. Mass.: | 69020.39 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q05769 |
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| Residue: | 604 |
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| Sequence: | MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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| BDBM50172473 |
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| n/a |
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| Name | BDBM50172473 |
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| Synonyms: | (-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid | (2R)-2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid | (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid | (R)-2-fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid | (R)-FLURBIPROFEN | CHEMBL190083 | Flurizan | Tarenflurbil |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13FO2 |
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| Mol. Mass. | 244.2609 |
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| SMILES | C[C@@H](C(O)=O)c1ccc(c(F)c1)-c1ccccc1 |
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| Structure | 
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