Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50394020 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_855921 (CHEMBL2161684) | ||
IC50 | >8000±n/a nM | ||
Citation | Scott, JS; Gill, AL; Godfrey, L; Groombridge, SD; Rees, A; Revill, J; Schofield, P; Sörme, P; Stocker, A; Swales, JG; Whittamore, PR Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors. Bioorg Med Chem Lett22:6756-61 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50394020 | |||
n/a | |||
Name | BDBM50394020 | ||
Synonyms: | CHEMBL2158473 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H29N3O2 | ||
Mol. Mass. | 343.4632 | ||
SMILES | Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C(C)(C)C |r,wU:8.7,wD:15.16,TLB:16:15:8:10.12.11,12:13:18:10.11.17,12:11:8.13.14:18,THB:7:8:18:10.11.17,17:11:8:14.15.18,17:15:8:10.12.11,(13.42,-15.26,;14.76,-14.49,;14.76,-12.95,;16.09,-12.18,;17.42,-12.94,;18.75,-12.17,;18.75,-10.63,;20.09,-12.93,;21.42,-12.16,;22.59,-10.85,;23.93,-11.32,;25.32,-10.94,;24.33,-12.24,;22.91,-11.7,;22.87,-10.11,;23.89,-8.86,;23.88,-7.32,;25.3,-9.42,;22.55,-9.37,;17.43,-14.49,;16.09,-15.27,;18.76,-15.26,;20.1,-14.49,;17.98,-16.59,;19.52,-16.59,)| | ||
Structure |