Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50394024 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_855921 (CHEMBL2161684) | ||
IC50 | 14800±n/a nM | ||
Citation | Scott, JS; Gill, AL; Godfrey, L; Groombridge, SD; Rees, A; Revill, J; Schofield, P; Sörme, P; Stocker, A; Swales, JG; Whittamore, PR Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors. Bioorg Med Chem Lett22:6756-61 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50394024 | |||
n/a | |||
Name | BDBM50394024 | ||
Synonyms: | CHEMBL2158477 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H25N3O2 | ||
Mol. Mass. | 363.4528 | ||
SMILES | Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)-c1ccccc1 |r,wU:8.7,wD:15.16,TLB:16:15:8:10.12.11,12:13:18:10.11.17,12:11:8.13.14:18,THB:7:8:18:10.11.17,17:11:8:14.15.18,17:15:8:10.12.11,(8.64,-40.39,;9.97,-39.62,;9.98,-38.08,;11.31,-37.31,;12.64,-38.07,;13.97,-37.3,;13.97,-35.76,;15.31,-38.06,;16.64,-37.29,;17.81,-35.98,;19.14,-36.45,;20.53,-36.07,;19.54,-37.37,;18.13,-36.83,;18.09,-35.24,;19.11,-33.99,;19.09,-32.45,;20.51,-34.55,;17.77,-34.5,;12.65,-39.62,;11.31,-40.4,;13.98,-40.39,;13.97,-41.93,;15.31,-42.7,;16.64,-41.93,;16.63,-40.38,;15.3,-39.62,)| | ||
Structure |