| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B10 |
|---|
| Ligand | BDBM50241487 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_857753 (CHEMBL2168780) |
|---|
| IC50 | 5900±n/a nM |
|---|
| Citation |  Takemura, M; Endo, S; Matsunaga, T; Soda, M; Zhao, HT; El-Kabbani, O; Tajima, K; Iinuma, M; Hara, A Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid. J Nat Prod74:1201-6 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B10 |
|---|
| Name: | Aldo-keto reductase family 1 member B10 |
|---|
| Synonyms: | AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36024.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60218. 1ZUA; 4JII; 4GQ0 |
|---|
| Residue: | 316 |
|---|
| Sequence: | MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
|
|
|
|---|
| BDBM50241487 |
|---|
| n/a |
|---|
| Name | BDBM50241487 |
|---|
| Synonyms: | 2,3,6,23-tetrahydroxyurs-12-en-28-oic acid | Asiatic acid | CHEMBL404313 | asiantic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H48O5 |
|---|
| Mol. Mass. | 488.6991 |
|---|
| SMILES | C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O |r,c:9| |
|---|
| Structure | 
|
|---|
Search and Browse
