Ki Summary

Reaction Details

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Target

Pyroglutamylated RF-amide peptide receptor

Ligand

BDBM50396425

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_862135 (CHEMBL2174320)

EC50

1367±n/a nM

Citation

Neveu, C; Lefranc, B; Tasseau, O; Do-Rego, JC; Bourmaud, A; Chan, P; Bauchat, P; Le Marec, O; Chuquet, J; Guilhaudis, L; Boutin, JA; Ségalas-Milazzo, I; Costentin, J; Vaudry, H; Baudy-Floc'h, M; Vaudry, D; Leprince, J Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-ß3-pseudopeptide agonist. J Med Chem55:7516-24 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Pyroglutamylated RF-amide peptide receptor

Name:

Pyroglutamylated RF-amide peptide receptor

Synonyms:

GPR103 | Pyroglutamylated RFamide peptide receptor | QRFPR | QRFPR_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49508.46

Organism:

Homo sapiens (Human)

Description:

GPR103 0 HUMAN::Q96P65

Residue:

431

Sequence:

MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALAL
FGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKM
VPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPM
WHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYE
LWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSN
FEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQ
RHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSE
LAENSPLDSGH

BDBM50396425

n/a

Name

BDBM50396425

Synonyms:

CHEMBL2170400

Type

Small organic molecule

Emp. Form.

C46H64N12O7

Mol. Mass.

897.0766

SMILES

[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#7](-[#6]-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r|

Structure