Found 149 hits with Last Name = 'leprince' and Initial = 'j' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002726
(CHEMBL2371933)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C51H64N10O11S2/c1-28(2)43(51(71)72)61-50(70)41-27-74-73-26-40(59-45(65)36-19-20-42(63)54-36)49(69)57-37(22-29-10-4-3-5-11-29)46(66)58-39(24-31-25-53-34-13-7-6-12-33(31)34)48(68)55-35(14-8-9-21-52)44(64)56-38(47(67)60-41)23-30-15-17-32(62)18-16-30/h3-7,10-13,15-18,25,28,35-41,43,53,62H,8-9,14,19-24,26-27,52H2,1-2H3,(H,54,63)(H,55,68)(H,56,64)(H,57,69)(H,58,66)(H,59,65)(H,60,67)(H,61,70)(H,71,72)/t35-,36-,37-,38-,39-,40-,41-,43-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002718
(CHEMBL385281)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2csc3ccccc23)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C52H64N10O11S3/c1-28(2)44(52(72)73)62-51(71)41-27-76-75-26-40(60-45(65)34(54)23-43(63)64)50(70)59-39(22-31-25-74-42-18-9-7-15-33(31)42)49(69)58-38(21-30-24-55-35-16-8-6-14-32(30)35)48(68)56-36(17-10-11-19-53)46(66)57-37(47(67)61-41)20-29-12-4-3-5-13-29/h3-9,12-16,18,24-25,28,34,36-41,44,55H,10-11,17,19-23,26-27,53-54H2,1-2H3,(H,56,68)(H,57,66)(H,58,69)(H,59,70)(H,60,65)(H,61,67)(H,62,71)(H,63,64)(H,72,73)/t34-,36-,37-,38-,39-,40-,41-,44-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50320463
(CHEMBL218994 | D[CFWKYC]V | H-Asp-Cys-Phe-Trp-Lys-...)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C50H64N10O12S2/c1-27(2)42(50(71)72)60-49(70)40-26-74-73-25-39(58-43(64)33(52)23-41(62)63)48(69)56-36(20-28-10-4-3-5-11-28)45(66)57-38(22-30-24-53-34-13-7-6-12-32(30)34)47(68)54-35(14-8-9-19-51)44(65)55-37(46(67)59-40)21-29-15-17-31(61)18-16-29/h3-7,10-13,15-18,24,27,33,35-40,42,53,61H,8-9,14,19-23,25-26,51-52H2,1-2H3,(H,54,68)(H,55,65)(H,56,69)(H,57,66)(H,58,64)(H,59,67)(H,60,70)(H,62,63)(H,71,72)/t33-,35-,36-,37-,38-,39-,40-,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002725
(CHEMBL374468)Show SMILES CN[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C51H66N10O12S2/c1-28(2)43(51(72)73)61-50(71)41-27-75-74-26-40(59-45(66)36(53-3)24-42(63)64)49(70)57-37(21-29-11-5-4-6-12-29)46(67)58-39(23-31-25-54-34-14-8-7-13-33(31)34)48(69)55-35(15-9-10-20-52)44(65)56-38(47(68)60-41)22-30-16-18-32(62)19-17-30/h4-8,11-14,16-19,25,28,35-41,43,53-54,62H,9-10,15,20-24,26-27,52H2,1-3H3,(H,55,69)(H,56,65)(H,57,70)(H,58,67)(H,59,66)(H,60,68)(H,61,71)(H,63,64)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,43-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002728
(CHEMBL218825)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)C(C)(C)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C50H66N10O10S2/c1-28(2)41(48(68)69)60-47(67)39-26-71-72-27-40(59-49(70)50(3,4)52)46(66)56-36(22-29-12-6-5-7-13-29)43(63)57-38(24-31-25-53-34-15-9-8-14-33(31)34)45(65)54-35(16-10-11-21-51)42(62)55-37(44(64)58-39)23-30-17-19-32(61)20-18-30/h5-9,12-15,17-20,25,28,35-41,53,61H,10-11,16,21-24,26-27,51-52H2,1-4H3,(H,54,65)(H,55,62)(H,56,66)(H,57,63)(H,58,64)(H,59,70)(H,60,67)(H,68,69)/t35-,36-,37-,38-,39-,40-,41-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002723
(CHEMBL265166)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)c(c2)[N+]([O-])=O)C(=O)N1)C(O)=O Show InChI InChI=1S/C50H63N11O14S2/c1-26(2)42(50(72)73)60-49(71)38-25-77-76-24-37(58-43(65)31(52)22-41(63)64)48(70)56-34(18-27-10-4-3-5-11-27)45(67)57-36(21-29-23-53-32-13-7-6-12-30(29)32)47(69)54-33(14-8-9-17-51)44(66)55-35(46(68)59-38)19-28-15-16-40(62)39(20-28)61(74)75/h3-7,10-13,15-16,20,23,26,31,33-38,42,53,62H,8-9,14,17-19,21-22,24-25,51-52H2,1-2H3,(H,54,69)(H,55,66)(H,56,70)(H,57,67)(H,58,65)(H,59,68)(H,60,71)(H,63,64)(H,72,73)/t31-,33-,34-,35-,36-,37-,38-,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002717
(CHEMBL216712)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C48H62N10O11S3/c1-26(2)40(48(68)69)58-47(67)38-25-72-71-24-37(56-41(61)31(50)22-39(59)60)46(66)55-36(21-29-13-10-18-70-29)45(65)54-35(20-28-23-51-32-15-7-6-14-30(28)32)44(64)52-33(16-8-9-17-49)42(62)53-34(43(63)57-38)19-27-11-4-3-5-12-27/h3-7,10-15,18,23,26,31,33-38,40,51H,8-9,16-17,19-22,24-25,49-50H2,1-2H3,(H,52,64)(H,53,62)(H,54,65)(H,55,66)(H,56,61)(H,57,63)(H,58,67)(H,59,60)(H,68,69)/t31-,33-,34-,35-,36-,37-,38-,40-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002727
(CHEMBL266651)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C51H66N10O12S2/c1-28(2)43(51(72)73)61-50(71)41-27-75-74-26-40(59-44(65)34(53)19-20-42(63)64)49(70)57-37(22-29-10-4-3-5-11-29)46(67)58-39(24-31-25-54-35-13-7-6-12-33(31)35)48(69)55-36(14-8-9-21-52)45(66)56-38(47(68)60-41)23-30-15-17-32(62)18-16-30/h3-7,10-13,15-18,25,28,34,36-41,43,54,62H,8-9,14,19-24,26-27,52-53H2,1-2H3,(H,55,69)(H,56,66)(H,57,70)(H,58,67)(H,59,65)(H,60,68)(H,61,71)(H,63,64)(H,72,73)/t34-,36-,37-,38-,39-,40-,41-,43-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002716
(CHEMBL383996)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(cc2)C(C)(C)C)C(=O)N1)C(O)=O Show InChI InChI=1S/C54H72N10O11S2/c1-30(2)45(53(74)75)64-52(73)43-29-77-76-28-42(62-46(67)36(56)26-44(65)66)51(72)60-39(23-31-13-7-6-8-14-31)48(69)61-41(25-33-27-57-37-16-10-9-15-35(33)37)50(71)58-38(17-11-12-22-55)47(68)59-40(49(70)63-43)24-32-18-20-34(21-19-32)54(3,4)5/h6-10,13-16,18-21,27,30,36,38-43,45,57H,11-12,17,22-26,28-29,55-56H2,1-5H3,(H,58,71)(H,59,68)(H,60,72)(H,61,69)(H,62,67)(H,63,70)(H,64,73)(H,65,66)(H,74,75)/t36-,38-,39-,40-,41-,42-,43-,45-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002719
(CHEMBL412179)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C50H65N11O11S2/c1-27(2)42(50(71)72)61-49(70)40-26-74-73-25-39(59-43(64)33(53)23-41(62)63)48(69)57-36(20-28-10-4-3-5-11-28)45(66)58-38(22-30-24-54-34-13-7-6-12-32(30)34)47(68)55-35(14-8-9-19-51)44(65)56-37(46(67)60-40)21-29-15-17-31(52)18-16-29/h3-7,10-13,15-18,24,27,33,35-40,42,54H,8-9,14,19-23,25-26,51-53H2,1-2H3,(H,55,68)(H,56,65)(H,57,69)(H,58,66)(H,59,64)(H,60,67)(H,61,70)(H,62,63)(H,71,72)/t33-,35-,36-,37-,38-,39-,40-,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002715
(CHEMBL376223)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(=O)N1)C(O)=O Show InChI InChI=1S/C50H69IN10O12S2/c1-26(2)42(50(72)73)61-49(71)39-25-75-74-24-38(59-43(65)32(53)22-41(63)64)48(70)57-35(19-27-10-4-3-5-11-27)45(67)58-37(21-29-23-54-33-13-7-6-12-30(29)33)47(69)55-34(14-8-9-17-52)44(66)56-36(46(68)60-39)20-28-15-16-40(62)31(51)18-28/h6-7,12-13,15-16,18,23,26-27,32,34-39,42,54,62H,3-5,8-11,14,17,19-22,24-25,52-53H2,1-2H3,(H,55,69)(H,56,66)(H,57,70)(H,58,67)(H,59,65)(H,60,68)(H,61,71)(H,63,64)(H,72,73)/t32-,34-,35-,36-,37-,38-,39-,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002720
(CHEMBL219356)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccc(cc2)C(C)(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C54H72N10O11S2/c1-30(2)45(53(74)75)64-52(73)43-29-77-76-28-42(62-46(67)36(56)26-44(65)66)51(72)60-40(24-32-18-20-34(21-19-32)54(3,4)5)48(69)61-41(25-33-27-57-37-16-10-9-15-35(33)37)50(71)58-38(17-11-12-22-55)47(68)59-39(49(70)63-43)23-31-13-7-6-8-14-31/h6-10,13-16,18-21,27,30,36,38-43,45,57H,11-12,17,22-26,28-29,55-56H2,1-5H3,(H,58,71)(H,59,68)(H,60,72)(H,61,69)(H,62,67)(H,63,70)(H,64,73)(H,65,66)(H,74,75)/t36-,38-,39-,40-,41-,42-,43-,45-/m0/s1 | Reactome pathway
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002724
(CHEMBL428990)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(cc2)C(O)=O)C(=O)N1)C(O)=O Show InChI InChI=1S/C51H64N10O13S2/c1-27(2)42(51(73)74)61-49(70)40-26-76-75-25-39(59-43(64)33(53)23-41(62)63)48(69)57-36(20-28-10-4-3-5-11-28)45(66)58-38(22-31-24-54-34-13-7-6-12-32(31)34)47(68)55-35(14-8-9-19-52)44(65)56-37(46(67)60-40)21-29-15-17-30(18-16-29)50(71)72/h3-7,10-13,15-18,24,27,33,35-40,42,54H,8-9,14,19-23,25-26,52-53H2,1-2H3,(H,55,68)(H,56,65)(H,57,69)(H,58,66)(H,59,64)(H,60,67)(H,61,70)(H,62,63)(H,71,72)(H,73,74)/t33-,35-,36-,37-,38-,39-,40-,42-/m0/s1 | Reactome pathway
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PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002722
(CHEMBL415851)Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O)NC(=O)[C@@H](N)CC(O)=O Show InChI InChI=1S/C47H66N10O12S2/c1-24(2)17-33-42(63)54-35(19-27-21-50-31-10-6-5-9-29(27)31)44(65)51-32(11-7-8-16-48)41(62)53-34(18-26-12-14-28(58)15-13-26)43(64)56-37(46(67)57-39(25(3)4)47(68)69)23-71-70-22-36(45(66)52-33)55-40(61)30(49)20-38(59)60/h5-6,9-10,12-15,21,24-25,30,32-37,39,50,58H,7-8,11,16-20,22-23,48-49H2,1-4H3,(H,51,65)(H,52,66)(H,53,62)(H,54,63)(H,55,61)(H,56,64)(H,57,67)(H,59,60)(H,68,69)/t30-,32-,33-,34-,35-,36-,37-,39-/m0/s1 | Reactome pathway
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| 132 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002713
(CHEMBL425467)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC(C)(C)[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C52H74N10O12S2/c1-28(2)42(51(73)74)61-49(71)40-27-75-76-52(3,4)43(62-44(66)34(54)25-41(64)65)50(72)59-38(22-29-12-6-5-7-13-29)46(68)58-39(24-31-26-55-35-15-9-8-14-33(31)35)48(70)56-36(16-10-11-21-53)45(67)57-37(47(69)60-40)23-30-17-19-32(63)20-18-30/h8-9,14-15,17-20,26,28-29,34,36-40,42-43,55,63H,5-7,10-13,16,21-25,27,53-54H2,1-4H3,(H,56,70)(H,57,67)(H,58,68)(H,59,72)(H,60,69)(H,61,71)(H,62,66)(H,64,65)(H,73,74)/t34-,36-,37-,38-,39-,40-,42-,43+/m0/s1 | Reactome pathway
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| 155 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002698
(CHEMBL437110)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C49H70N10O10S2/c1-27(2)41(49(68)69)59-48(67)40-26-71-70-25-39(57-42(61)28(3)51)47(66)55-36(21-29-11-5-4-6-12-29)44(63)56-38(23-31-24-52-34-14-8-7-13-33(31)34)46(65)53-35(15-9-10-20-50)43(62)54-37(45(64)58-40)22-30-16-18-32(60)19-17-30/h7-8,13-14,16-19,24,27-29,35-41,52,60H,4-6,9-12,15,20-23,25-26,50-51H2,1-3H3,(H,53,65)(H,54,62)(H,55,66)(H,56,63)(H,57,61)(H,58,64)(H,59,67)(H,68,69)/t28-,35-,36-,37-,38-,39-,40-,41-/m0/s1 | Reactome pathway
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| 263 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50411186
(CHEMBL218698)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C50H70N10O12S2/c1-27(2)42(50(71)72)60-49(70)40-26-74-73-25-39(58-43(64)33(52)23-41(62)63)48(69)56-36(20-28-10-4-3-5-11-28)45(66)57-38(22-30-24-53-34-13-7-6-12-32(30)34)47(68)54-35(14-8-9-19-51)44(65)55-37(46(67)59-40)21-29-15-17-31(61)18-16-29/h6-7,12-13,15-18,24,27-28,33,35-40,42,53,61H,3-5,8-11,14,19-23,25-26,51-52H2,1-2H3,(H,54,68)(H,55,65)(H,56,69)(H,57,66)(H,58,64)(H,59,67)(H,60,70)(H,62,63)(H,71,72)/t33-,35-,36-,37-,38-,39-,40-,42-/m0/s1 | Reactome pathway
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| 407 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002721
(CHEMBL415850)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)N2C3CCCCC3CC2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C49H68N10O10S2/c1-27(2)42(49(68)69)58-47(66)37-25-70-71-26-40(57-43(62)32(51)23-41(60)61)59-38-18-9-6-14-29(38)22-39(59)48(67)55-36(21-30-24-52-33-16-8-7-15-31(30)33)46(65)53-34(17-10-11-19-50)44(63)54-35(45(64)56-37)20-28-12-4-3-5-13-28/h3-5,7-8,12-13,15-16,24,27,29,32,34-40,42,52H,6,9-11,14,17-23,25-26,50-51H2,1-2H3,(H,53,65)(H,54,63)(H,55,67)(H,56,64)(H,57,62)(H,58,66)(H,60,61)(H,68,69)/t29?,32-,34-,35-,36-,37-,38?,39?,40+,42-/m0/s1 | Reactome pathway
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PubMed
| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Urotensin-2 receptor
(Homo sapiens (Human)) | BDBM50002714
(CHEMBL216716)Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@H](CC2CCCCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O Show InChI InChI=1S/C50H70N10O12S2/c1-27(2)42(50(71)72)60-49(70)40-26-74-73-25-39(58-43(64)33(52)23-41(62)63)48(69)56-36(20-28-10-4-3-5-11-28)45(66)57-38(22-30-24-53-34-13-7-6-12-32(30)34)47(68)54-35(14-8-9-19-51)44(65)55-37(46(67)59-40)21-29-15-17-31(61)18-16-29/h6-7,12-13,15-18,24,27-28,33,35-40,42,53,61H,3-5,8-11,14,19-23,25-26,51-52H2,1-2H3,(H,54,68)(H,55,65)(H,56,69)(H,57,66)(H,58,64)(H,59,67)(H,60,70)(H,62,63)(H,71,72)/t33-,35-,36+,37-,38-,39-,40-,42-/m0/s1 | Reactome pathway
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]human urotensin-2 from human GPR14 transfected in CHO cells |
J Med Chem 49: 7234-8 (2006)
Checked by Author
Article DOI: 10.1021/jm0602110
BindingDB Entry DOI: 10.7270/Q29G5P1V |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347818
(CHEMBL1802413 | P518)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C127H195N37O37/c1-66(2)49-83(160-124(200)94-35-24-48-164(94)101(176)62-144-110(186)91(63-165)163-125(201)104(132)70(8)168)108(184)142-61-100(175)148-90(57-96(131)171)121(197)157-84(50-67(3)4)116(192)145-69(7)106(182)149-80(40-42-102(177)178)114(190)154-81(41-43-103(179)180)115(191)156-85(51-68(5)6)117(193)159-89(56-95(130)170)109(185)143-60-99(174)147-87(55-74-36-38-75(169)39-37-74)119(195)161-92(64-166)122(198)153-78(33-22-46-138-126(134)135)112(188)151-77(32-19-21-45-129)111(187)150-76(31-18-20-44-128)107(183)141-58-97(172)140-59-98(173)146-86(53-72-27-14-10-15-28-72)118(194)162-93(65-167)123(199)158-88(54-73-29-16-11-17-30-73)120(196)152-79(34-23-47-139-127(136)137)113(189)155-82(105(133)181)52-71-25-12-9-13-26-71/h9-17,25-30,36-39,66-70,76-94,104,165-169H,18-24,31-35,40-65,128-129,132H2,1-8H3,(H2,130,170)(H2,131,171)(H2,133,181)(H,140,172)(H,141,183)(H,142,184)(H,143,185)(H,144,186)(H,145,192)(H,146,173)(H,147,174)(H,148,175)(H,149,182)(H,150,187)(H,151,188)(H,152,196)(H,153,198)(H,154,190)(H,155,189)(H,156,191)(H,157,197)(H,158,199)(H,159,193)(H,160,200)(H,161,195)(H,162,194)(H,163,201)(H,177,178)(H,179,180)(H4,134,135,138)(H4,136,137,139)/t69-,70+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,104-/m0/s1 | UniProtKB/SwissProt
antibodypedia
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PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469449
(CHEMBL4277047)Show SMILES C[C+]1CN(Cc2ccc(CN(C)C)cc12)C(=O)c1cc2cc(Br)ncc2n1C Show InChI InChI=1S/C22H24BrN4O/c1-14-11-27(13-16-6-5-15(7-18(14)16)12-25(2)3)22(28)19-8-17-9-21(23)24-10-20(17)26(19)4/h5-10H,11-13H2,1-4H3/q+1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 579 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396422
(CHEMBL2170403)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6](-[#8])-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-1-[#6]-[#6]-[#7]-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C44H62N12O8/c45-40(61)35(23-30-11-4-1-5-12-30)53-41(62)34(17-10-18-49-44(46)47)52-42(63)36(24-31-13-6-2-7-14-31)50-39(60)28-56(26-33(58)29-57)54-43(64)37(25-32-15-8-3-9-16-32)51-38(59)27-55-21-19-48-20-22-55/h1-9,11-16,33-37,48,57-58H,10,17-29H2,(H2,45,61)(H,50,60)(H,51,59)(H,52,63)(H,53,62)(H,54,64)(H4,46,47,49)/t33?,34-,35-,36-,37-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | 1.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396420
(CHEMBL2170390)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C40H54N12O8/c41-22-33(54)52-46-23-34(55)47-30(20-26-13-6-2-7-14-26)37(58)51-32(24-53)39(60)50-31(21-27-15-8-3-9-16-27)38(59)48-28(17-10-18-45-40(43)44)36(57)49-29(35(42)56)19-25-11-4-1-5-12-25/h1-9,11-16,28-32,46,53H,10,17-24,41H2,(H2,42,56)(H,47,55)(H,48,59)(H,49,57)(H,50,60)(H,51,58)(H,52,54)(H4,43,44,45)/t28-,29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | 2.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469440
(CHEMBL4281854)Show SMILES CN(C)C(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C42H57N11O8/c1-53(2)42(45)46-20-12-19-30(38(58)50-31(37(44)57)21-27-13-6-3-7-14-27)49-40(60)33(23-29-17-10-5-11-18-29)51-41(61)34(26-54)52-39(59)32(22-28-15-8-4-9-16-28)48-36(56)25-47-35(55)24-43/h3-11,13-18,30-34,54H,12,19-26,43H2,1-2H3,(H2,44,57)(H2,45,46)(H,47,55)(H,48,56)(H,49,60)(H,50,58)(H,51,61)(H,52,59)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | 6.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469430
(CHEMBL4279100)Show SMILES C\N=C(/NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C |r| Show InChI InChI=1S/C43H59N11O8/c1-46-43(54(2)3)47-21-13-20-31(39(59)51-32(38(45)58)22-28-14-7-4-8-15-28)50-41(61)34(24-30-18-11-6-12-19-30)52-42(62)35(27-55)53-40(60)33(23-29-16-9-5-10-17-29)49-37(57)26-48-36(56)25-44/h4-12,14-19,31-35,55H,13,20-27,44H2,1-3H3,(H2,45,58)(H,46,47)(H,48,56)(H,49,57)(H,50,61)(H,51,59)(H,52,62)(H,53,60)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | 8.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347830
(CHEMBL1802425)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C40H53N11O8/c41-22-33(53)46-23-34(54)47-30(20-26-13-6-2-7-14-26)37(57)51-32(24-52)39(59)50-31(21-27-15-8-3-9-16-27)38(58)48-28(17-10-18-45-40(43)44)36(56)49-29(35(42)55)19-25-11-4-1-5-12-25/h1-9,11-16,28-32,52H,10,17-24,41H2,(H2,42,55)(H,46,53)(H,47,54)(H,48,58)(H,49,56)(H,50,59)(H,51,57)(H4,43,44,45)/t28-,29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | 8.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396416
(CHEMBL2170398)Show SMILES [#6]-[#6]-[#6]-[#7](-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7] |r| Show InChI InChI=1S/C42H58N12O7/c1-2-21-54(53-41(61)34(24-30-17-10-5-11-18-30)49-36(56)26-48-35(55)25-43)27-37(57)50-33(23-29-15-8-4-9-16-29)40(60)51-31(19-12-20-47-42(45)46)39(59)52-32(38(44)58)22-28-13-6-3-7-14-28/h3-11,13-18,31-34H,2,12,19-27,43H2,1H3,(H2,44,58)(H,48,55)(H,49,56)(H,50,57)(H,51,60)(H,52,59)(H,53,61)(H4,45,46,47)/t31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as inhibition of human 26RFa-induced increase in intracell... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396419
(CHEMBL2170393)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#7](-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O)-[#6]-c1ccccc1 |r| Show InChI InChI=1S/C40H54N12O8/c41-21-33(54)46-22-34(55)48-31(20-27-13-6-2-7-14-27)38(59)50-32(25-53)39(60)51-52(23-28-15-8-3-9-16-28)24-35(56)47-29(17-10-18-45-40(43)44)37(58)49-30(36(42)57)19-26-11-4-1-5-12-26/h1-9,11-16,29-32,53H,10,17-25,41H2,(H2,42,57)(H,46,54)(H,47,56)(H,48,55)(H,49,58)(H,50,59)(H,51,60)(H4,43,44,45)/t29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as inhibition of human 26RFa-induced increase in intracell... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396418
(CHEMBL2170394)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#7](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C40H54N12O8/c41-22-33(54)46-23-34(55)48-30(20-27-13-6-2-7-14-27)37(58)50-32(25-53)38(59)49-31(21-28-15-8-3-9-16-28)39(60)51-52(18-10-17-45-40(43)44)24-35(56)47-29(36(42)57)19-26-11-4-1-5-12-26/h1-9,11-16,29-32,53H,10,17-25,41H2,(H2,42,57)(H,46,54)(H,47,56)(H,48,55)(H,49,59)(H,50,58)(H,51,60)(H4,43,44,45)/t29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as inhibition of human 26RFa-induced increase in intracell... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396417
(CHEMBL2170395)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#7](-[#6]-[#6](-[#7])=O)-[#6]-c1ccccc1 |r| Show InChI InChI=1S/C40H54N12O8/c41-21-34(55)46-22-35(56)47-30(19-26-11-4-1-5-12-26)36(57)50-32(25-53)38(59)49-31(20-27-13-6-2-7-14-27)37(58)48-29(17-10-18-45-40(43)44)39(60)51-52(24-33(42)54)23-28-15-8-3-9-16-28/h1-9,11-16,29-32,53H,10,17-25,41H2,(H2,42,54)(H,46,55)(H,47,56)(H,48,58)(H,49,59)(H,50,57)(H,51,60)(H4,43,44,45)/t29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as inhibition of human 26RFa-induced increase in intracell... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469426
(CHEMBL4292045)Show SMILES CNC(=N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C42H57N11O8/c1-46-42(45)47-20-12-11-19-30(38(58)51-31(37(44)57)21-27-13-5-2-6-14-27)50-40(60)33(23-29-17-9-4-10-18-29)52-41(61)34(26-54)53-39(59)32(22-28-15-7-3-8-16-28)49-36(56)25-48-35(55)24-43/h2-10,13-18,30-34,54H,11-12,19-26,43H2,1H3,(H2,44,57)(H,48,55)(H,49,56)(H,50,60)(H,51,58)(H,52,61)(H,53,59)(H3,45,46,47)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469438
(CHEMBL4285426)Show SMILES NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N1CCC1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C43H57N11O8/c44-25-36(56)48-26-37(57)49-33(23-29-14-6-2-7-15-29)40(60)53-35(27-55)42(62)52-34(24-30-16-8-3-9-17-30)41(61)50-31(18-10-19-47-43(46)54-20-11-21-54)39(59)51-32(38(45)58)22-28-12-4-1-5-13-28/h1-9,12-17,31-35,55H,10-11,18-27,44H2,(H2,45,58)(H2,46,47)(H,48,56)(H,49,57)(H,50,61)(H,51,59)(H,52,62)(H,53,60)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469435
(CHEMBL4289249)Show SMILES CCCNC(=N)NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C42H57N11O8/c1-2-19-46-42(45)47-20-18-30(38(58)51-31(37(44)57)21-27-12-6-3-7-13-27)50-40(60)33(23-29-16-10-5-11-17-29)52-41(61)34(26-54)53-39(59)32(22-28-14-8-4-9-15-28)49-36(56)25-48-35(55)24-43/h3-17,30-34,54H,2,18-26,43H2,1H3,(H2,44,57)(H,48,55)(H,49,56)(H,50,60)(H,51,58)(H,52,61)(H,53,59)(H3,45,46,47)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469432
(CHEMBL4277540)Show SMILES CCN(CC)C(=N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C45H63N11O8/c1-3-56(4-2)45(48)49-23-15-14-22-33(41(61)53-34(40(47)60)24-30-16-8-5-9-17-30)52-43(63)36(26-32-20-12-7-13-21-32)54-44(64)37(29-57)55-42(62)35(25-31-18-10-6-11-19-31)51-39(59)28-50-38(58)27-46/h5-13,16-21,33-37,57H,3-4,14-15,22-29,46H2,1-2H3,(H2,47,60)(H2,48,49)(H,50,58)(H,51,59)(H,52,63)(H,53,61)(H,54,64)(H,55,62)/t33-,34-,35-,36-,37-/m0/s1 | UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469452
(CHEMBL4282993)Show SMILES CN(C)C(=N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C43H59N11O8/c1-54(2)43(46)47-21-13-12-20-31(39(59)51-32(38(45)58)22-28-14-6-3-7-15-28)50-41(61)34(24-30-18-10-5-11-19-30)52-42(62)35(27-55)53-40(60)33(23-29-16-8-4-9-17-29)49-37(57)26-48-36(56)25-44/h3-11,14-19,31-35,55H,12-13,20-27,44H2,1-2H3,(H2,45,58)(H2,46,47)(H,48,56)(H,49,57)(H,50,61)(H,51,59)(H,52,62)(H,53,60)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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UniChem
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469424
(CHEMBL4288232)Show SMILES NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C39H51N11O8/c40-21-32(52)45-22-33(53)46-29(19-25-12-6-2-7-13-25)36(56)50-31(23-51)38(58)49-30(20-26-14-8-3-9-15-26)37(57)47-27(16-17-44-39(42)43)35(55)48-28(34(41)54)18-24-10-4-1-5-11-24/h1-15,27-31,51H,16-23,40H2,(H2,41,54)(H,45,52)(H,46,53)(H,47,57)(H,48,55)(H,49,58)(H,50,56)(H4,42,43,44)/t27-,28-,29-,30-,31-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469451
(CHEMBL4289785)Show SMILES C\N=C(\NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C |r| Show InChI InChI=1S/C42H57N11O8/c1-45-42(53(2)3)46-20-19-30(38(58)50-31(37(44)57)21-27-13-7-4-8-14-27)49-40(60)33(23-29-17-11-6-12-18-29)51-41(61)34(26-54)52-39(59)32(22-28-15-9-5-10-16-28)48-36(56)25-47-35(55)24-43/h4-18,30-34,54H,19-26,43H2,1-3H3,(H2,44,57)(H,45,46)(H,47,55)(H,48,56)(H,49,60)(H,50,58)(H,51,61)(H,52,59)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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| Article
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469448
(CHEMBL4286672)Show SMILES CC(C)CNC(=N)NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C43H59N11O8/c1-27(2)24-49-43(46)47-19-18-31(39(59)52-32(38(45)58)20-28-12-6-3-7-13-28)51-41(61)34(22-30-16-10-5-11-17-30)53-42(62)35(26-55)54-40(60)33(21-29-14-8-4-9-15-29)50-37(57)25-48-36(56)23-44/h3-17,27,31-35,55H,18-26,44H2,1-2H3,(H2,45,58)(H,48,56)(H,50,57)(H,51,61)(H,52,59)(H,53,62)(H,54,60)(H3,46,47,49)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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UniChem
| Article
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469447
(CHEMBL4291594)Show SMILES CCN(CC)C(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C44H61N11O8/c1-3-55(4-2)44(47)48-22-14-21-32(40(60)52-33(39(46)59)23-29-15-8-5-9-16-29)51-42(62)35(25-31-19-12-7-13-20-31)53-43(63)36(28-56)54-41(61)34(24-30-17-10-6-11-18-30)50-38(58)27-49-37(57)26-45/h5-13,15-20,32-36,56H,3-4,14,21-28,45H2,1-2H3,(H2,46,59)(H2,47,48)(H,49,57)(H,50,58)(H,51,62)(H,52,60)(H,53,63)(H,54,61)/t32-,33-,34-,35-,36-/m0/s1 | UniProtKB/SwissProt
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| Article
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469431
(CHEMBL4282568)Show SMILES CCNC(=N)NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C41H55N11O8/c1-2-45-41(44)46-19-18-29(37(57)50-30(36(43)56)20-26-12-6-3-7-13-26)49-39(59)32(22-28-16-10-5-11-17-28)51-40(60)33(25-53)52-38(58)31(21-27-14-8-4-9-15-27)48-35(55)24-47-34(54)23-42/h3-17,29-33,53H,2,18-25,42H2,1H3,(H2,43,56)(H,47,54)(H,48,55)(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H3,44,45,46)/t29-,30-,31-,32-,33-/m0/s1 | UniProtKB/SwissProt
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UniChem
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PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469445
(CHEMBL4294578)Show SMILES CCCNC(=N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C44H61N11O8/c1-2-21-48-44(47)49-22-13-12-20-32(40(60)53-33(39(46)59)23-29-14-6-3-7-15-29)52-42(62)35(25-31-18-10-5-11-19-31)54-43(63)36(28-56)55-41(61)34(24-30-16-8-4-9-17-30)51-38(58)27-50-37(57)26-45/h3-11,14-19,32-36,56H,2,12-13,20-28,45H2,1H3,(H2,46,59)(H,50,57)(H,51,58)(H,52,62)(H,53,60)(H,54,63)(H,55,61)(H3,47,48,49)/t32-,33-,34-,35-,36-/m0/s1 | UniProtKB/SwissProt
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UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469444
(CHEMBL4284790)Show SMILES CCN(C)C(=N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C44H61N11O8/c1-3-55(2)44(47)48-22-14-13-21-32(40(60)52-33(39(46)59)23-29-15-7-4-8-16-29)51-42(62)35(25-31-19-11-6-12-20-31)53-43(63)36(28-56)54-41(61)34(24-30-17-9-5-10-18-30)50-38(58)27-49-37(57)26-45/h4-12,15-20,32-36,56H,3,13-14,21-28,45H2,1-2H3,(H2,46,59)(H2,47,48)(H,49,57)(H,50,58)(H,51,62)(H,52,60)(H,53,63)(H,54,61)/t32-,33-,34-,35-,36-/m0/s1 | UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469433
(CHEMBL4288190)Show SMILES CCN(C)C(=N)NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C42H57N11O8/c1-3-53(2)42(45)46-20-19-30(38(58)50-31(37(44)57)21-27-13-7-4-8-14-27)49-40(60)33(23-29-17-11-6-12-18-29)51-41(61)34(26-54)52-39(59)32(22-28-15-9-5-10-16-28)48-36(56)25-47-35(55)24-43/h4-18,30-34,54H,3,19-26,43H2,1-2H3,(H2,44,57)(H2,45,46)(H,47,55)(H,48,56)(H,49,60)(H,50,58)(H,51,61)(H,52,59)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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UniChem
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PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469443
(CHEMBL4280959)Show SMILES CCN(CC)C(=N)NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C43H59N11O8/c1-3-54(4-2)43(46)47-21-20-31(39(59)51-32(38(45)58)22-28-14-8-5-9-15-28)50-41(61)34(24-30-18-12-7-13-19-30)52-42(62)35(27-55)53-40(60)33(23-29-16-10-6-11-17-29)49-37(57)26-48-36(56)25-44/h5-19,31-35,55H,3-4,20-27,44H2,1-2H3,(H2,45,58)(H2,46,47)(H,48,56)(H,49,57)(H,50,61)(H,51,59)(H,52,62)(H,53,60)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469441
(CHEMBL4286363)Show SMILES CN\C(NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)=N\C |r| Show InChI InChI=1S/C42H57N11O8/c1-45-42(46-2)47-20-12-19-30(38(58)51-31(37(44)57)21-27-13-6-3-7-14-27)50-40(60)33(23-29-17-10-5-11-18-29)52-41(61)34(26-54)53-39(59)32(22-28-15-8-4-9-16-28)49-36(56)25-48-35(55)24-43/h3-11,13-18,30-34,54H,12,19-26,43H2,1-2H3,(H2,44,57)(H,48,55)(H,49,56)(H,50,60)(H,51,58)(H,52,61)(H,53,59)(H2,45,46,47)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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UniChem
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PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469428
(CHEMBL4290858)Show SMILES CN\C(NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)=N/C |r| Show InChI InChI=1S/C41H55N11O8/c1-44-41(45-2)46-19-18-29(37(57)50-30(36(43)56)20-26-12-6-3-7-13-26)49-39(59)32(22-28-16-10-5-11-17-28)51-40(60)33(25-53)52-38(58)31(21-27-14-8-4-9-15-27)48-35(55)24-47-34(54)23-42/h3-17,29-33,53H,18-25,42H2,1-2H3,(H2,43,56)(H,47,54)(H,48,55)(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H2,44,45,46)/t29-,30-,31-,32-,33-/m0/s1 | UniProtKB/SwissProt
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UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469427
(CHEMBL4289720)Show SMILES CN(C)C(=N)NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C41H55N11O8/c1-52(2)41(44)45-19-18-29(37(57)49-30(36(43)56)20-26-12-6-3-7-13-26)48-39(59)32(22-28-16-10-5-11-17-28)50-40(60)33(25-53)51-38(58)31(21-27-14-8-4-9-15-27)47-35(55)24-46-34(54)23-42/h3-17,29-33,53H,18-25,42H2,1-2H3,(H2,43,56)(H2,44,45)(H,46,54)(H,47,55)(H,48,59)(H,49,57)(H,50,60)(H,51,58)/t29-,30-,31-,32-,33-/m0/s1 | UniProtKB/SwissProt
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469420
(CHEMBL4288630)Show SMILES CNC(=N)NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C40H53N11O8/c1-44-40(43)45-18-17-28(36(56)49-29(35(42)55)19-25-11-5-2-6-12-25)48-38(58)31(21-27-15-9-4-10-16-27)50-39(59)32(24-52)51-37(57)30(20-26-13-7-3-8-14-26)47-34(54)23-46-33(53)22-41/h2-16,28-32,52H,17-24,41H2,1H3,(H2,42,55)(H,46,53)(H,47,54)(H,48,58)(H,49,56)(H,50,59)(H,51,57)(H3,43,44,45)/t28-,29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469421
(CHEMBL4287681)Show SMILES NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCNC(=N)N1CCC1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C44H59N11O8/c45-26-37(57)49-27-38(58)50-34(24-30-15-6-2-7-16-30)41(61)54-36(28-56)43(63)53-35(25-31-17-8-3-9-18-31)42(62)51-32(19-10-11-20-48-44(47)55-21-12-22-55)40(60)52-33(39(46)59)23-29-13-4-1-5-14-29/h1-9,13-18,32-36,56H,10-12,19-28,45H2,(H2,46,59)(H2,47,48)(H,49,57)(H,50,58)(H,51,62)(H,52,60)(H,53,63)(H,54,61)/t32-,33-,34-,35-,36-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469422
(CHEMBL4293167)Show SMILES C\N=C(\NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C |r| Show InChI InChI=1S/C44H61N11O8/c1-47-44(55(2)3)48-22-14-13-21-32(40(60)52-33(39(46)59)23-29-15-7-4-8-16-29)51-42(62)35(25-31-19-11-6-12-20-31)53-43(63)36(28-56)54-41(61)34(24-30-17-9-5-10-18-30)50-38(58)27-49-37(57)26-45/h4-12,15-20,32-36,56H,13-14,21-28,45H2,1-3H3,(H2,46,59)(H,47,48)(H,49,57)(H,50,58)(H,51,62)(H,52,60)(H,53,63)(H,54,61)/t32-,33-,34-,35-,36-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Antagonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as inhibition of 26RFa-induced Ca2+ mobilization preincubat... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
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