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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Ligand | BDBM50380675 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_873372 (CHEMBL2185623) | ||
| IC50 | 50.12±n/a nM | ||
| Citation |  Seal, J; Lamotte, Y; Donche, F; Bouillot, A; Mirguet, O; Gellibert, F; Nicodeme, E; Krysa, G; Kirilovsky, J; Beinke, S; McCleary, S; Rioja, I; Bamborough, P; Chung, CW; Gordon, L; Lewis, T; Walker, AL; Cutler, L; Lugo, D; Wilson, DM; Witherington, J; Lee, K; Prinjha, RK Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett22:2968-72 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
| Type: | Protein | ||
| Mol. Mass.: | 83318.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07343 | ||
| Residue: | 736 | ||
| Sequence: |
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| BDBM50380675 | |||
| n/a | |||
| Name | BDBM50380675 | ||
| Synonyms: | CHEMBL2017281 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H21N5O3 | ||
| Mol. Mass. | 439.4659 | ||
| SMILES | COc1cc2c(Nc3cccc4cccnc34)c(cnc2cc1-c1c(C)noc1C)C(N)=O |(39.67,-12.44,;39.67,-13.98,;41,-14.75,;42.33,-13.98,;43.67,-14.75,;44.99,-13.97,;44.98,-12.43,;43.65,-11.67,;42.33,-12.45,;40.99,-11.7,;40.98,-10.15,;42.31,-9.37,;42.3,-7.85,;43.62,-7.07,;44.96,-7.83,;44.97,-9.37,;43.64,-10.14,;46.33,-14.73,;46.34,-16.28,;45,-17.06,;43.67,-16.29,;42.33,-17.07,;41,-16.3,;39.67,-17.07,;39.63,-18.61,;40.86,-19.54,;38.16,-19.06,;37.28,-17.79,;38.21,-16.56,;37.76,-15.09,;47.66,-13.96,;49,-14.72,;47.65,-12.42,)| | ||
| Structure | 
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