| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-gamma serine/threonine-protein kinase |
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| Ligand | BDBM50398368 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_875914 (CHEMBL2188027) |
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| IC50 | 5±n/a nM |
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| Citation |  Blake, JF; Xu, R; Bencsik, JR; Xiao, D; Kallan, NC; Schlachter, S; Mitchell, IS; Spencer, KL; Banka, AL; Wallace, EM; Gloor, SL; Martinson, M; Woessner, RD; Vigers, GP; Brandhuber, BJ; Liang, J; Safina, BS; Li, J; Zhang, B; Chabot, C; Do, S; Lee, L; Oeh, J; Sampath, D; Lee, BB; Lin, K; Liederer, BM; Skelton, NJ Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem55:8110-27 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-gamma serine/threonine-protein kinase |
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| Name: | RAC-gamma serine/threonine-protein kinase |
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| Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55769.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 479 |
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| Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
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| BDBM50398368 |
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| n/a |
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| Name | BDBM50398368 |
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| Synonyms: | CHEMBL2177379 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30ClN5O2 |
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| Mol. Mass. | 455.98 |
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| SMILES | C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCN3)c3ccc(Cl)cc3)c12 |r| |
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| Structure | 
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