Reaction Details | |||
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Target | RAC-beta serine/threonine-protein kinase | ||
Ligand | BDBM50398366 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_875912 (CHEMBL2188025) | ||
IC50 | 10±n/a nM | ||
Citation | Blake, JF; Xu, R; Bencsik, JR; Xiao, D; Kallan, NC; Schlachter, S; Mitchell, IS; Spencer, KL; Banka, AL; Wallace, EM; Gloor, SL; Martinson, M; Woessner, RD; Vigers, GP; Brandhuber, BJ; Liang, J; Safina, BS; Li, J; Zhang, B; Chabot, C; Do, S; Lee, L; Oeh, J; Sampath, D; Lee, BB; Lin, K; Liederer, BM; Skelton, NJ Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem55:8110-27 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
RAC-beta serine/threonine-protein kinase | |||
Name: | RAC-beta serine/threonine-protein kinase | ||
Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta | ||
Type: | Enzyme | ||
Mol. Mass.: | 55766.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 481 | ||
Sequence: |
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BDBM50398366 | |||
n/a | |||
Name | BDBM50398366 | ||
Synonyms: | CHEMBL2177367 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H38ClN5O3 | ||
Mol. Mass. | 528.086 | ||
SMILES | CO[C@H]1CC[C@@H](CC1)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1 |r,wU:27.29,10.10,5.8,wD:24.26,2.1,(22.8,-34.77,;21.46,-35.53,;21.46,-37.07,;20.12,-37.83,;20.11,-39.37,;21.44,-40.13,;22.77,-39.38,;22.78,-37.85,;21.44,-41.67,;20.11,-42.44,;20.11,-43.98,;21.44,-44.75,;22.78,-43.98,;21.44,-46.3,;20.11,-47.07,;20.11,-48.61,;21.44,-49.38,;22.78,-48.61,;22.78,-47.07,;21.44,-50.92,;22.78,-51.68,;22.77,-53.23,;21.43,-54,;20.09,-53.22,;18.64,-53.7,;18.17,-55.16,;17.74,-52.46,;18.63,-51.21,;18.15,-49.75,;20.09,-51.69,;18.77,-44.75,;18.77,-46.29,;17.45,-47.06,;16.1,-46.29,;14.77,-47.06,;16.1,-44.75,;17.44,-43.97,)| | ||
Structure |