| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50398392 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_876347 (CHEMBL2185821) |
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| Ki | 4680±n/a nM |
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| Citation |  Corona, P; Gibellini, F; Cavalli, A; Saxena, P; Carta, A; Loriga, M; Luciani, R; Paglietti, G; Guerrieri, D; Nerini, E; Gupta, S; Hannaert, V; Michels, PA; Ferrari, S; Costi, PM Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors. J Med Chem55:8318-29 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50398392 |
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| n/a |
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| Name | BDBM50398392 |
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| Synonyms: | CHEMBL2178603 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N8O3 |
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| Mol. Mass. | 464.5202 |
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| SMILES | CCc1ccc(NCc2cnc3nc(N)nc(N)c3n2)cc1C(=O)N1CCC(CC1)C(=O)OC |
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| Structure | 
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