Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50398575 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_873519 (CHEMBL2187021) | ||
IC50 | 98±n/a nM | ||
Citation | Takahashi, Y; Hashizume, M; Shin, K; Terauchi, T; Takeda, K; Hibi, S; Murata-Tai, K; Fujisawa, M; Shikata, K; Taguchi, R; Ino, M; Shibata, H; Yonaga, M Design, synthesis, and structure-activity relationships of novel pyrazolo[5,1-b]thiazole derivatives as potent and orally active corticotropin-releasing factor 1 receptor antagonists. J Med Chem55:8450-63 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50398575 | |||
n/a | |||
Name | BDBM50398575 | ||
Synonyms: | CHEMBL2179186 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H33N3O5S | ||
Mol. Mass. | 475.601 | ||
SMILES | CCCN(C1CCOCC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(COC)cc1OC |(17.83,-21.66,;19.37,-21.66,;20.13,-20.32,;21.67,-20.32,;22.39,-18.95,;23.94,-18.91,;24.66,-17.55,;23.84,-16.24,;22.3,-16.29,;21.57,-17.66,;22.22,-21.76,;21.34,-23.03,;19.8,-23.06,;19.06,-24.41,;22.27,-24.25,;23.73,-23.74,;25.2,-24.19,;26.08,-22.92,;25.15,-21.7,;23.69,-22.21,;25.95,-25.53,;25.16,-26.85,;23.62,-26.83,;22.82,-28.15,;25.9,-28.2,;27.44,-28.23,;28.19,-29.58,;29.73,-29.6,;30.48,-30.95,;28.24,-26.91,;27.49,-25.56,;28.28,-24.24,;29.82,-24.26,)| | ||
Structure |