Reaction Details |
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Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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Ligand | BDBM50398649 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_874730 (CHEMBL2187963) |
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IC50 | 21±n/a nM |
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Citation | Meng, F; Hou, J; Shao, YX; Wu, PY; Huang, M; Zhu, X; Cai, Y; Li, Z; Xu, J; Liu, P; Luo, HB; Wan, Y; Ke, H Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design. J Med Chem55:8549-58 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
Type: | Protein |
Mol. Mass.: | 68488.40 |
Organism: | Homo sapiens (Human) |
Description: | O76083 |
Residue: | 593 |
Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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BDBM50398649 |
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n/a |
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Name | BDBM50398649 |
Synonyms: | CHEMBL2178115 | US9617269, Compound WYQ-94-D |
Type | Small organic molecule |
Emp. Form. | C21H19ClN6O3 |
Mol. Mass. | 438.867 |
SMILES | COc1ccc(NC(=O)C(C)Nc2nc3n(ncc3c(=O)[nH]2)-c2ccccc2Cl)cc1 |
Structure |
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