| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 8 |
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| Ligand | BDBM50398743 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_876226 (CHEMBL2183982) |
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| EC50 | >30000±n/a nM |
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| Citation |  Sidique, S; Dhanya, RP; Sheffler, DJ; Nickols, HH; Yang, L; Dahl, R; Mangravita-Novo, A; Smith, LH; D'Souza, MS; Semenova, S; Conn, PJ; Markou, A; Cosford, ND Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence. J Med Chem55:9434-45 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 8 |
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| Name: | Metabotropic glutamate receptor 8 |
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| Synonyms: | GRM8_RAT | Gprc1h | Grm8 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 8 (mGlu8) | Mglur8 | glutamate receptor, metabotropic 8 precursor | mGlu8 | metabotropic glutamate 8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 101886.18 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P70579 |
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| Residue: | 908 |
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| Sequence: | MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINN
KSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
TIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
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| BDBM50398743 |
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| n/a |
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| Name | BDBM50398743 |
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| Synonyms: | CHEMBL2179631 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27NO5 |
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| Mol. Mass. | 457.5177 |
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| SMILES | COc1ccc(cc1-c1cccc(COc2ccc3C(=O)N(Cc3c2)C2CCCC2)c1)C(O)=O |
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| Structure | 
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