Reaction Details |
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Target | G-protein coupled bile acid receptor 1 |
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Ligand | BDBM50399966 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_877860 (CHEMBL2187734) |
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EC50 | 0.72±n/a nM |
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Citation | Duan, H; Ning, M; Chen, X; Zou, Q; Zhang, L; Feng, Y; Zhang, L; Leng, Y; Shen, J Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J Med Chem55:10475-89 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled bile acid receptor 1 |
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Name: | G-protein coupled bile acid receptor 1 |
Synonyms: | BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 35260.02 |
Organism: | Homo sapiens (Human) |
Description: | CHO cells transiently transfected with hTGR5. |
Residue: | 330 |
Sequence: | MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
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BDBM50399966 |
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n/a |
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Name | BDBM50399966 |
Synonyms: | CHEMBL2181226 |
Type | Small organic molecule |
Emp. Form. | C25H25N3O2 |
Mol. Mass. | 399.4849 |
SMILES | Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc23)c1 |
Structure |
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