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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50400143 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_878466 (CHEMBL2187380) | ||
| IC50 | 30±n/a nM | ||
| Citation |  Goldberg, FW; Leach, AG; Scott, JS; Snelson, WL; Groombridge, SD; Donald, CS; Bennett, SN; Bodin, C; Gutierrez, PM; Gyte, AC Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. J Med Chem55:10652-61 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM50400143 | |||
| n/a | |||
| Name | BDBM50400143 | ||
| Synonyms: | CHEMBL2179445 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H30N4O3 | ||
| Mol. Mass. | 398.4986 | ||
| SMILES | O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(N[C@@H]4CCOC4)nc1C1CC1)C(C3)C2 |r,wU:7.8,wD:1.0,16.16,TLB:0:1:7:27.3.4,8:7:6.28.1:27.3.4,8:7:4:6.1.2,THB:0:1:7.26.27:4,2:1:7:27.3.4,2:3:7:6.28.1,28:26:4:6.1.2,28:1:7.26.27:4,(30.73,-3.51,;29.2,-3.49,;28.16,-2.37,;26.74,-2.92,;26.09,-4.19,;27.12,-5.27,;28.42,-4.71,;27.13,-7.01,;25.8,-7.78,;24.46,-7.02,;24.46,-5.48,;23.13,-7.79,;21.8,-7.03,;20.47,-7.8,;20.47,-9.35,;19.13,-10.11,;17.8,-9.34,;16.4,-9.96,;15.37,-8.82,;16.14,-7.49,;17.65,-7.81,;21.8,-10.12,;23.14,-9.34,;24.47,-10.11,;25.25,-11.45,;26.02,-10.11,;27.93,-5.68,;26.76,-4.36,;29.34,-5.12,)| | ||
| Structure | 
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