Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50400161 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_878466 (CHEMBL2187380) | ||
IC50 | 13±n/a nM | ||
Citation | Goldberg, FW; Leach, AG; Scott, JS; Snelson, WL; Groombridge, SD; Donald, CS; Bennett, SN; Bodin, C; Gutierrez, PM; Gyte, AC Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. J Med Chem55:10652-61 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50400161 | |||
n/a | |||
Name | BDBM50400161 | ||
Synonyms: | CHEMBL2179441 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H30N4O4 | ||
Mol. Mass. | 402.4873 | ||
SMILES | CC(C)Oc1nc(NC2COC2)ncc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:18.19,wD:25.28,TLB:26:25:18:22.21.20,17:18:28.24.25:22.21.20,17:18:20:28.25.27,THB:26:25:18.23.22:20,27:25:18:22.21.20,27:21:18:28.24.25,24:23:20:28.25.27,24:25:18.23.22:20,(68.49,-40.84,;67.16,-40.07,;65.82,-40.85,;67.16,-38.53,;65.82,-37.76,;64.48,-38.54,;63.15,-37.77,;61.81,-38.53,;60.47,-37.76,;60.08,-36.27,;58.59,-36.67,;58.99,-38.16,;63.15,-36.22,;64.48,-35.45,;65.81,-36.21,;67.15,-35.44,;67.14,-33.89,;68.48,-36.2,;69.82,-35.42,;69.81,-33.68,;68.77,-32.6,;69.43,-31.33,;69.45,-32.77,;70.62,-34.1,;72.03,-33.53,;71.89,-31.91,;73.42,-31.92,;70.84,-30.78,;71.11,-33.12,)| | ||
Structure |