| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase K |
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| Ligand | BDBM50400619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_880183 (CHEMBL2214885) |
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| IC50 | >80000±n/a nM |
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| Citation |  Wityak, J; Prime, ME; Brookfield, FA; Courtney, SM; Erfan, S; Johnsen, S; Johnson, PD; Li, M; Marston, RW; Reed, L; Vaidya, D; Schaertl, S; Pedret-Dunn, A; Beconi, M; Macdonald, D; Muņoz-Sanjuan, I; Dominguez, C SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease. ACS Med Chem Lett3:1024-1028 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-glutamine gamma-glutamyltransferase K |
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| Name: | Protein-glutamine gamma-glutamyltransferase K |
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| Synonyms: | KTG | Protein-glutamine gamma-glutamyltransferase K | TGM1 | TGM1_HUMAN | Transglutaminase-1 (TG1) |
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| Type: | Protein |
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| Mol. Mass.: | 89778.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 817 |
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| Sequence: | MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDD
WGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSS
RSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTH
VIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPR
NEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDA
CLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVE
ILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDEN
MKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESI
KNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDI
TYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVML
INHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLV
DQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVT
LTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHG
VIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
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| BDBM50400619 |
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| n/a |
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| Name | BDBM50400619 |
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| Synonyms: | CHEMBL2203476 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H33N3O6 |
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| Mol. Mass. | 447.5246 |
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| SMILES | CC(C)(C)OC(=O)CNC(=O)[C@H](CCCCNC(=O)C=C)NC(=O)OCc1ccccc1 |r| |
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| Structure | 
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