| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform gamma-2 |
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| Ligand | BDBM50400749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_880536 (CHEMBL2211471) |
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| IC50 | 33±n/a nM |
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| Citation |  Huang, H; Acquaviva, L; Berry, V; Bregman, H; Chakka, N; DiMauro, EF; Dovey, J; Epstein, O; Grubinska, B; Goldstein, J; Gunaydin, H; Hua, Z; Huang, X; Huang, L; Human, J; Long, A; Newcomb, J; Patel, VF; Saffran, D; Serafino, R; Schneider, S; Strathdee, C; Tang, J; Turci, S; White, R; Yu, V; Zhao, H; Wilson, C; Martin, MW Structure-Based Design of Potent and Selective CK1¿ Inhibitors. ACS Med Chem Lett3:1059-1064 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform gamma-2 |
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| Name: | Casein kinase I isoform gamma-2 |
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| Synonyms: | CK1G2 | CSNK1G2 | Casein kinase I | Casein kinase I gamma 2 | KC1G2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47475.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774313 |
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| Residue: | 415 |
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| Sequence: | MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGEL
RLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLE
LLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKR
QHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH
MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFF
EKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSK
NQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
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| BDBM50400749 |
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| n/a |
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| Name | BDBM50400749 |
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| Synonyms: | CHEMBL2203555 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5O2 |
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| Mol. Mass. | 349.3865 |
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| SMILES | COc1cnc(NCc2ccccc2)nc1-c1cc2c(CCNC2=O)[nH]1 |
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| Structure | 
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