Ki Summary

Reaction Details

Report a problem with these data

Target

Neuropeptides B/W receptor type 1

Ligand

BDBM75925

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_887068 (CHEMBL2213859)

IC50

12200±n/a nM

Citation

Urbano, M; Guerrero, M; Zhao, J; Velaparthi, S; Saldanha, SA; Chase, P; Wang, Z; Civelli, O; Hodder, P; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7). Bioorg Med Chem Lett22:7135-41 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptides B/W receptor type 1

Name:

Neuropeptides B/W receptor type 1

Synonyms:

GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

36111.82

Organism:

Homo sapiens (Human)

Description:

gi_119607128

Residue:

328

Sequence:

MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLY
VLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNT
FSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD
DEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAK
ALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANS
CLNPFLYAFLDASFRRNLRQLITCRAAA

BDBM75925

n/a

Name

BDBM75925

Synonyms:

5-chloranyl-2-(4-propan-2-ylphenyl)-4-[4-(trifluoromethyloxy)phenoxy]pyridazin-3-one | 5-chloro-2-(4-propan-2-ylphenyl)-4-[4-(trifluoromethoxy)phenoxy]-3-pyridazinone | 5-chloro-2-(4-propan-2-ylphenyl)-4-[4-(trifluoromethoxy)phenoxy]pyridazin-3-one | 5-chloro-2-p-cumenyl-4-[4-(trifluoromethoxy)phenoxy]pyridazin-3-one | SR-02000000458 | SR-02000000458-1 | cid_46835812

Type

Small organic molecule

Emp. Form.

C20H16ClF3N2O3

Mol. Mass.

424.801

SMILES

CC(C)c1ccc(cc1)-n1ncc(Cl)c(Oc2ccc(OC(F)(F)F)cc2)c1=O

Structure