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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Procathepsin L | ||
| Ligand | BDBM50401766 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_885154 (CHEMBL2213245) | ||
| IC50 | 600±n/a nM | ||
| Citation |  Moss, N; Xiong, Z; Burke, M; Cogan, D; Gao, DA; Haverty, K; Heim-Riether, A; Hickey, ER; Nagaraja, R; Netherton, M; O'Shea, K; Ramsden, P; Schwartz, R; Shih, DT; Ward, Y; Young, E; Zhang, Q Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement. Bioorg Med Chem Lett22:7189-93 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Procathepsin L | |||
| Name: | Procathepsin L | ||
| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 37557.19 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Purchased from Calbiochem (San Diego, CA). | ||
| Residue: | 333 | ||
| Sequence: |
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| BDBM50401766 | |||
| n/a | |||
| Name | BDBM50401766 | ||
| Synonyms: | CHEMBL2207562 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H31N5OS | ||
| Mol. Mass. | 413.579 | ||
| SMILES | CCCC[C@H](C#N)n1cc(nn1)[C@@](C)(NC(=O)c1ccsc1)[C@H]1CC[C@H](C)CC1 |r,wU:12.13,25.27,wD:12.14,22.24,4.6,(20.99,-15.82,;19.45,-15.89,;18.74,-17.26,;17.2,-17.33,;16.49,-18.7,;17.32,-20,;18.15,-21.29,;14.95,-18.77,;14.09,-20.05,;12.62,-19.64,;12.54,-18.1,;13.98,-17.56,;11.41,-20.6,;10.62,-21.92,;10.07,-19.83,;8.74,-20.6,;8.74,-22.14,;7.51,-19.66,;6.04,-20.11,;5.16,-18.84,;6.09,-17.61,;7.55,-18.12,;12.17,-21.92,;11.39,-23.24,;12.14,-24.56,;13.67,-24.57,;14.43,-25.92,;14.44,-23.26,;13.69,-21.93,)| | ||
| Structure | 
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