| Reaction Details |
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 | Report a problem with these data |
| Target | c-Jun N-terminal kinase, JNK |
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| Ligand | BDBM50402841 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_884764 |
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| IC50 | 30±n/a nM |
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| Citation |  Gong L; Tan YC; Boice G; Abbot S; McCaleb K; Iyer P; Zuo F; Dal Porto J; Wong B; Jin S; Chang A; Tran P; Hsieh G; Niu L; Shao A; Reuter D; Lukacs CM; Ursula Kammlott R; Kuglstatter A; Goldstein D Discovery of a novel series of 4-quinolone JNK inhibitors. Bioorg Med Chem Lett 22:7381-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| c-Jun N-terminal kinase, JNK |
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| Name: | c-Jun N-terminal kinase, JNK |
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| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | Mitogen-Activated Protein Kinase 8 (JNK1) | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48297.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 427 |
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| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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| BDBM50402841 |
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| n/a |
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| Name | BDBM50402841 |
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| Synonyms: | CHEMBL2204108 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26ClN3O5S |
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| Mol. Mass. | 552.041 |
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| SMILES | COC(=O)c1c(Cc2ccc(cc2)S(=O)(=O)N2CCNCC2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 |
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| Structure | 
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