| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM50404957 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_84892 |
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| Ki | 15849±n/a nM |
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| Citation |  Hoffman, JM; Pietruszkiewicz, AM; Habecker, CN; Phillips, BT; Bolhofer, WA; Cragoe, EJ; Torchiana, ML; Lumma, WC; Baldwin, JJ Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine. J Med Chem26:140-4 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40567.22 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
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| Residue: | 359 |
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| Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
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| BDBM50404957 |
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| n/a |
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| Name | BDBM50404957 |
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| Synonyms: | CHEMBL33996 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15N5O2 |
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| Mol. Mass. | 273.2905 |
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| SMILES | CNC([CH-][N+]([O-])=O)=[NH+]c1cccc(c1)-c1nc[nH]c1C |w:7.7| |
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| Structure | 
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