| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50408517 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48330 (CHEMBL663319) |
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| Ki | 27±n/a nM |
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| Citation |  Thompson, SK; Smith, WW; Zhao, B; Halbert, SM; Tomaszek, TA; Tew, DG; Levy, MA; Janson, CA; DAlessio, KJ; McQueney, MS; Kurdyla, J; Jones, CS; DesJarlais, RL; Abdel-Meguid, SS; Veber, DF Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic. J Med Chem41:3923-7 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50408517 |
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| n/a |
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| Name | BDBM50408517 |
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| Synonyms: | CHEMBL340191 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33N5O6 |
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| Mol. Mass. | 547.6022 |
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| SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NNC(=O)NNC(=O)c1cccc(OCc2ccccc2)c1 |r| |
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| Structure | 
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