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TargetCathepsin K
LigandBDBM50408522
Substrate/Competitorn/a
Meas. Tech.ChEMBL_48330
Ki 0.8±n/a nM
Citation Thompson SKSmith WWZhao BHalbert SMTomaszek TATew DGLevy MAJanson CADAlessio KJMcQueney MSKurdyla JJones CSDesJarlais RLAbdel-Meguid SSVeber DF Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic. J Med Chem 41:3923-7 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:Enzyme
Mol. Mass.:36975.68
Organism:Homo sapiens (Human)
Description:P43235
Residue:329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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  Blast E-value cutoff:
BDBM50408522
n/a
NameBDBM50408522
Synonyms:CHEMBL126820
TypeSmall organic molecule
Emp. Form.C28H38N6O7
Mol. Mass.570.6373
SMILESCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NNC(=O)NNC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Structure
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