| Reaction Details |
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 | Report a problem with these data |
| Target | Growth hormone secretagogue receptor type 1 |
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| Ligand | BDBM50410133 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_310274 (CHEMBL833105) |
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| EC50 | 1.5±n/a nM |
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| Citation |  Li, JJ; Wang, H; Qu, F; Musial, C; Tino, JA; Robl, JA; Slusarchyk, D; Golla, R; Seethala, R; Dickinson, K; Giupponi, L; Grover, G; Sleph, P; Flynn, N; Murphy, BJ; Gordon, D; Kung, M; Stoffel, R Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues. Bioorg Med Chem Lett15:1799-802 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth hormone secretagogue receptor type 1 |
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| Name: | Growth hormone secretagogue receptor type 1 |
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| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
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| Type: | Receptor |
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| Mol. Mass.: | 41334.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
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| Residue: | 366 |
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| Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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| BDBM50410133 |
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| n/a |
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| Name | BDBM50410133 |
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| Synonyms: | CHEMBL181063 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H40F3N3O4 |
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| Mol. Mass. | 563.6515 |
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| SMILES | CC(C)N(CCNC(=O)C1N(CCc2cc(Oc3cccc(c3)C(F)(F)F)ccc12)C(=O)OC(C)(C)C)C(C)C |
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| Structure | 
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