Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50411070 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_372592 (CHEMBL868679) |
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IC50 | >5000±n/a nM |
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Citation | Brugel, TA; Maier, JA; Clark, MP; Sabat, M; Golebiowski, A; Bookland, RG; Laufersweiler, MJ; Laughlin, SK; Vanrens, JC; De, B; Hsieh, LC; Mekel, MJ; Janusz, MJ Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1. Bioorg Med Chem Lett16:3510-3 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50411070 |
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n/a |
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Name | BDBM50411070 |
Synonyms: | CHEMBL208736 |
Type | Small organic molecule |
Emp. Form. | C22H22ClFN6O |
Mol. Mass. | 440.901 |
SMILES | CN1CCN(CC1)c1nccc(n1)N(C(=O)Nc1ccccc1Cl)c1ccc(F)cc1 |
Structure |
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