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TargetAmine oxidase [flavin-containing] B
LigandBDBM50031038
Substrate/Competitorn/a
Meas. Tech.ChEMBL_417162 (CHEMBL909463)
IC50 9549.93±n/a nM
Citation Novaroli, L; Daina, A; Favre, E; Bravo, J; Carotti, A; Leonetti, F; Catto, M; Carrupt, PA; Reist, M Impact of species-dependent differences on screening, design, and development of MAO B inhibitors. J Med Chem49:6264-72 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Amine oxidase [flavin-containing] B
Name:Amine oxidase [flavin-containing] B
Synonyms:AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:Enzyme
Mol. Mass.:58469.65
Organism:Rattus norvegicus (rat)
Description:P19643
Residue:520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50031038
n/a
NameBDBM50031038
Synonyms:4-Benzyl-3-phenyl-indeno[1,2-c]pyridazin-5-one | 4-benzyl-3-phenyl-5H-indeno[1,2-c]pyridazin-5-one | CHEMBL128029
TypeSmall organic molecule
Emp. Form.C24H16N2O
Mol. Mass.348.3966
SMILESO=C1c2ccccc2-c2nnc(-c3ccccc3)c(Cc3ccccc3)c12
Structure
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