Reaction Details |
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Target | Cholecystokinin receptor type A |
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Ligand | BDBM50410544 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_439004 (CHEMBL889350) |
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Ki | <10000±n/a nM |
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Citation | McDonald, IM; Black, JW; Buck, IM; Dunstone, DJ; Griffin, EP; Harper, EA; Hull, RA; Kalindjian, SB; Lilley, EJ; Linney, ID; Pether, MJ; Roberts, SP; Shaxted, ME; Spencer, J; Steel, KI; Sykes, DA; Walker, MK; Watt, GF; Wright, L; Wright, PT; Xun, W Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion. J Med Chem50:3101-12 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholecystokinin receptor type A |
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Name: | Cholecystokinin receptor type A |
Synonyms: | CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 47859.34 |
Organism: | Homo sapiens (Human) |
Description: | Stable expression of human CCK-1 receptors in HEK 293 cells. |
Residue: | 428 |
Sequence: | MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
MSASVPPQ
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BDBM50410544 |
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n/a |
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Name | BDBM50410544 |
Synonyms: | CHEMBL390519 |
Type | Small organic molecule |
Emp. Form. | C28H35N3O4 |
Mol. Mass. | 477.5952 |
SMILES | OC(=O)c1cccc(NC(=O)c2[nH]c(nc2COC23CC4CC(CC(C4)C2)C3)C2CCCCC2)c1 |TLB:17:18:21:25.24.23,THB:19:20:23:27.18.26,19:18:21.20.25:23,17:18:21.20.25:23,26:18:21:25.24.23,26:24:21:27.19.18| |
Structure |
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