| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP1 subtype |
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| Ligand | BDBM50412241 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_487569 (CHEMBL1022752) |
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| Ki | 50.12±n/a nM |
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| Citation |  Hall, A; Billinton, A; Bristow, AK; Brown, SH; Chowdhury, A; Cutler, L; Giblin, GM; Goldsmith, P; Hayhow, TG; Kilford, IR; Naylor, A; Passingham, B; Rawlings, DA Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists. Bioorg Med Chem Lett18:4027-32 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP1 subtype |
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| Name: | Prostaglandin E2 receptor EP1 subtype |
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| Synonyms: | PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 41834.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34995 |
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| Residue: | 402 |
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| Sequence: | MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA
AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFF
GLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYE
LQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRR
PPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLV
GIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLR
QLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
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| BDBM50412241 |
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| n/a |
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| Name | BDBM50412241 |
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| Synonyms: | CHEMBL495091 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H35ClN4O2 |
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| Mol. Mass. | 495.056 |
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| SMILES | CCN1CCc2ccc(cc2CC1)C(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCC(C)C)n1 |
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| Structure | 
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