Found 147 hits with Last Name = 'kilford' and Initial = 'ir' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160917
(3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...)Show SMILES OC(=O)c1cccc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1 Show InChI InChI=1S/C24H17ClO3S/c25-19-9-10-22(28-15-16-5-2-1-3-6-16)21(14-19)20-11-12-29-23(20)17-7-4-8-18(13-17)24(26)27/h1-14H,15H2,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity against PGE2 activated EP1 receptor assessed as ability to inhibit intracellular calcium mobilisation by FLIPR |
Bioorg Med Chem Lett 16: 2666-71 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.014
BindingDB Entry DOI: 10.7270/Q2J102RM |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412231
(CHEMBL520438)Show SMILES Cc1cc(nn1Cc1cc(Cl)ccc1OCc1ccccc1)C(=O)Nc1ccc(CO)cc1 Show InChI InChI=1S/C26H24ClN3O3/c1-18-13-24(26(32)28-23-10-7-19(16-31)8-11-23)29-30(18)15-21-14-22(27)9-12-25(21)33-17-20-5-3-2-4-6-20/h2-14,31H,15-17H2,1H3,(H,28,32) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 39.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412241
(CHEMBL495091)Show SMILES CCN1CCc2ccc(cc2CC1)C(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCC(C)C)n1 Show InChI InChI=1S/C28H35ClN4O2/c1-5-32-12-10-21-6-7-23(15-22(21)11-13-32)28(34)30-27-14-20(4)33(31-27)17-24-16-25(29)8-9-26(24)35-18-19(2)3/h6-9,14-16,19H,5,10-13,17-18H2,1-4H3,(H,30,31,34) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 50.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412232
(CHEMBL523216)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(cc1C)C(=O)Nc1ccc(CN(CCO)CCO)cc1 Show InChI InChI=1S/C27H35ClN4O4/c1-19(2)18-36-26-9-6-23(28)15-22(26)17-32-20(3)14-25(30-32)27(35)29-24-7-4-21(5-8-24)16-31(10-12-33)11-13-34/h4-9,14-15,19,33-34H,10-13,16-18H2,1-3H3,(H,29,35) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 79.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412224
(CHEMBL479591)Show SMILES Cc1cc(nn1Cc1cc(Cl)ccc1OCc1ccccc1)C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C30H31ClN4O3/c1-22-17-28(30(36)32-27-10-7-23(8-11-27)19-34-13-15-37-16-14-34)33-35(22)20-25-18-26(31)9-12-29(25)38-21-24-5-3-2-4-6-24/h2-12,17-18H,13-16,19-21H2,1H3,(H,32,36) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 79.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412239
(CHEMBL492237)Show SMILES CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 Show InChI InChI=1S/C24H29ClN4O2/c1-16(2)15-31-23-10-7-20(25)12-19(23)14-29-17(3)11-22(28-29)24(30)27-21-8-5-18(6-9-21)13-26-4/h5-12,16,26H,13-15H2,1-4H3,(H,27,30) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 79.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412209
(CHEMBL494466)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(NC(=O)c2ccc(cc2)C2CCCN2)cc1C Show InChI InChI=1S/C26H31ClN4O2/c1-17(2)16-33-24-11-10-22(27)14-21(24)15-31-18(3)13-25(30-31)29-26(32)20-8-6-19(7-9-20)23-5-4-12-28-23/h6-11,13-14,17,23,28H,4-5,12,15-16H2,1-3H3,(H,29,30,32) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412233
(CHEMBL495107)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(cc1C)C(=O)Nc1ccc(CNCCO)cc1 Show InChI InChI=1S/C25H31ClN4O3/c1-17(2)16-33-24-9-6-21(26)13-20(24)15-30-18(3)12-23(29-30)25(32)28-22-7-4-19(5-8-22)14-27-10-11-31/h4-9,12-13,17,27,31H,10-11,14-16H2,1-3H3,(H,28,32) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412225
(CHEMBL480789)Show SMILES CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 Show InChI InChI=1S/C27H27ClN4O2/c1-19-14-25(27(33)30-24-11-8-20(9-12-24)16-29-2)31-32(19)17-22-15-23(28)10-13-26(22)34-18-21-6-4-3-5-7-21/h3-15,29H,16-18H2,1-2H3,(H,30,33) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412208
(CHEMBL493254)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(NC(=O)c2ccc3CNCCc3c2)cc1C Show InChI InChI=1S/C25H29ClN4O2/c1-16(2)15-32-23-7-6-22(26)12-21(23)14-30-17(3)10-24(29-30)28-25(31)19-4-5-20-13-27-9-8-18(20)11-19/h4-7,10-12,16,27H,8-9,13-15H2,1-3H3,(H,28,29,31) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412213
(CHEMBL481689)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(NC(=O)c2ccc(CN3CCCC3)cc2)cc1C Show InChI InChI=1S/C27H33ClN4O2/c1-19(2)18-34-25-11-10-24(28)15-23(25)17-32-20(3)14-26(30-32)29-27(33)22-8-6-21(7-9-22)16-31-12-4-5-13-31/h6-11,14-15,19H,4-5,12-13,16-18H2,1-3H3,(H,29,30,33) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412215
(CHEMBL481870)Show SMILES CCNCc1ccc(cc1)C(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCC(C)C)n1 Show InChI InChI=1S/C25H31ClN4O2/c1-5-27-14-19-6-8-20(9-7-19)25(31)28-24-12-18(4)30(29-24)15-21-13-22(26)10-11-23(21)32-16-17(2)3/h6-13,17,27H,5,14-16H2,1-4H3,(H,28,29,31) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity of human PGE2 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium mobilisation by FLIPR assay |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase/Collagenase 3/Interstitial collagenase/Matrix metalloproteinase-9/Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50290085
((2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)c2ccccc2C1=O)C(=O)NO)C(C)(C)C Show InChI InChI=1S/C24H34N4O6/c1-13(2)11-16(19(29)26-18(21(31)25-6)24(3,4)5)17(20(30)27-34)12-28-22(32)14-9-7-8-10-15(14)23(28)33/h7-10,13,16-18,34H,11-12H2,1-6H3,(H,25,31)(H,26,29)(H,27,30)/t16-,17-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors) |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase/Collagenase 3/Interstitial collagenase/Matrix metalloproteinase-9/Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50290088
((2S,3R)-N*1*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)N(C)C(C)(C)C1=O)C(=O)NO)C(C)(C)C Show InChI InChI=1S/C22H39N5O6/c1-12(2)10-13(16(28)24-15(18(30)23-8)21(3,4)5)14(17(29)25-33)11-27-19(31)22(6,7)26(9)20(27)32/h12-15,33H,10-11H2,1-9H3,(H,23,30)(H,24,28)(H,25,29)/t13-,14-,15+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors) |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50290089
((2R,3R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](C)C(=O)NO)C(C)(C)C Show InChI InChI=1S/C16H31N3O4/c1-9(2)8-11(10(3)13(20)19-23)14(21)18-12(15(22)17-7)16(4,5)6/h9-12,23H,8H2,1-7H3,(H,17,22)(H,18,21)(H,19,20)/t10-,11-,12+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human gelatinase B, MMP9 |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50197898
(6-(2-(2-(2,4-difluorobenzyloxy)-5-chlorophenyl)cyc...)Show SMILES OC(=O)c1cccc(n1)C1=C(CCC1)c1cc(Cl)ccc1OCc1ccc(F)cc1F |t:10| Show InChI InChI=1S/C24H18ClF2NO3/c25-15-8-10-23(31-13-14-7-9-16(26)12-20(14)27)19(11-15)17-3-1-4-18(17)21-5-2-6-22(28-21)24(29)30/h2,5-12H,1,3-4,13H2,(H,29,30) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase/Collagenase 3/Interstitial collagenase/Matrix metalloproteinase-9/Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50290089
((2R,3R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](C)C(=O)NO)C(C)(C)C Show InChI InChI=1S/C16H31N3O4/c1-9(2)8-11(10(3)13(20)19-23)14(21)18-12(15(22)17-7)16(4,5)6/h9-12,23H,8H2,1-7H3,(H,17,22)(H,18,21)(H,19,20)/t10-,11-,12+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors) |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50290088
((2S,3R)-N*1*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)N(C)C(C)(C)C1=O)C(=O)NO)C(C)(C)C Show InChI InChI=1S/C22H39N5O6/c1-12(2)10-13(16(28)24-15(18(30)23-8)21(3,4)5)14(17(29)25-33)11-27-19(31)22(6,7)26(9)20(27)32/h12-15,33H,10-11H2,1-9H3,(H,23,30)(H,24,28)(H,25,29)/t13-,14-,15+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human gelatinase B, MMP9 |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50423557
(CHEMBL403330)Show InChI InChI=1S/C16H17ClO4/c1-10(2)9-20-14-5-3-12(17)7-11(14)8-13-4-6-15(21-13)16(18)19/h3-7,10H,8-9H2,1-2H3,(H,18,19)/p-1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50290085
((2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)c2ccccc2C1=O)C(=O)NO)C(C)(C)C Show InChI InChI=1S/C24H34N4O6/c1-13(2)11-16(19(29)26-18(21(31)25-6)24(3,4)5)17(20(30)27-34)12-28-22(32)14-9-7-8-10-15(14)23(28)33/h7-10,13,16-18,34H,11-12H2,1-6H3,(H,25,31)(H,26,29)(H,27,30)/t16-,17-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human gelatinase B, MMP9 |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase/Collagenase 3/Interstitial collagenase/Matrix metalloproteinase-9/Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50290086
((R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)-pro...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C Show InChI InChI=1S/C15H29N3O4/c1-9(2)7-10(8-11(19)18-22)13(20)17-12(14(21)16-6)15(3,4)5/h9-10,12,22H,7-8H2,1-6H3,(H,16,21)(H,17,20)(H,18,19)/t10-,12+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors) |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160917
(3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...)Show SMILES OC(=O)c1cccc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1 Show InChI InChI=1S/C24H17ClO3S/c25-19-9-10-22(28-15-16-5-2-1-3-6-16)21(14-19)20-11-12-29-23(20)17-7-4-8-18(13-17)24(26)27/h1-14H,15H2,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO-K1 cells |
Bioorg Med Chem Lett 16: 2666-71 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.014
BindingDB Entry DOI: 10.7270/Q2J102RM |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50423570
(CHEMBL209800)Show SMILES CC(C)COc1ccc(Cl)cc1-c1ccc(C)n1-c1cccc(c1)C(O)=O Show InChI InChI=1S/C22H22ClNO3/c1-14(2)13-27-21-10-8-17(23)12-19(21)20-9-7-15(3)24(20)18-6-4-5-16(11-18)22(25)26/h4-12,14H,13H2,1-3H3,(H,25,26) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412237
(CHEMBL492238)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(cc1C)C(=O)Nc1ccc(CN(C)C)cc1 Show InChI InChI=1S/C25H31ClN4O2/c1-17(2)16-32-24-11-8-21(26)13-20(24)15-30-18(3)12-23(28-30)25(31)27-22-9-6-19(7-10-22)14-29(4)5/h6-13,17H,14-16H2,1-5H3,(H,27,31) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50423574
(CHEMBL255652)Show InChI InChI=1S/C18H14ClNO3S/c19-14-6-7-16(23-10-12-4-2-1-3-5-12)13(8-14)9-17-20-15(11-24-17)18(21)22/h1-8,11H,9-10H2,(H,21,22)/p-1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50191163
(1-(2-(benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazo...)Show InChI InChI=1S/C19H17BrN2O3/c1-13-9-17(19(23)24)21-22(13)11-15-10-16(20)7-8-18(15)25-12-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,23,24) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50423563
(CHEMBL272793)Show InChI InChI=1S/C19H15ClO4/c20-15-6-8-17(23-12-13-4-2-1-3-5-13)14(10-15)11-16-7-9-18(24-16)19(21)22/h1-10H,11-12H2,(H,21,22)/p-1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412231
(CHEMBL520438)Show SMILES Cc1cc(nn1Cc1cc(Cl)ccc1OCc1ccccc1)C(=O)Nc1ccc(CO)cc1 Show InChI InChI=1S/C26H24ClN3O3/c1-18-13-24(26(32)28-23-10-7-19(16-31)8-11-23)29-30(18)15-21-14-22(27)9-12-25(21)33-17-20-5-3-2-4-6-20/h2-14,31H,15-17H2,1H3,(H,28,32) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412235
(CHEMBL493065)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(cc1C)C(=O)Nc1ccc(CN2CCCCC2)cc1 Show InChI InChI=1S/C28H35ClN4O2/c1-20(2)19-35-27-12-9-24(29)16-23(27)18-33-21(3)15-26(31-33)28(34)30-25-10-7-22(8-11-25)17-32-13-5-4-6-14-32/h7-12,15-16,20H,4-6,13-14,17-19H2,1-3H3,(H,30,34) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412236
(CHEMBL494282)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(cc1C)C(=O)Nc1ccc(CN2CCCC2)cc1 Show InChI InChI=1S/C27H33ClN4O2/c1-19(2)18-34-26-11-8-23(28)15-22(26)17-32-20(3)14-25(30-32)27(33)29-24-9-6-21(7-10-24)16-31-12-4-5-13-31/h6-11,14-15,19H,4-5,12-13,16-18H2,1-3H3,(H,29,33) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase/Collagenase 3/Interstitial collagenase/Matrix metalloproteinase-9/Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50290090
((2S,3R)-3-Cyclopentylmethyl-N-hydroxy-4-oxo-4-pipe...)Show SMILES CN1C(=O)N(C[C@H]([C@@H](CC2CCCC2)C(=O)N2CCCCC2)C(=O)NO)C(=O)C1(C)C Show InChI InChI=1S/C22H36N4O5/c1-22(2)20(29)26(21(30)24(22)3)14-17(18(27)23-31)16(13-15-9-5-6-10-15)19(28)25-11-7-4-8-12-25/h15-17,31H,4-14H2,1-3H3,(H,23,27)/t16-,17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors) |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50183185
(3-(2-(2-(benzyloxy)-5-chlorophenyl)-5-methyl-1H-py...)Show SMILES Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(c1)C(O)=O Show InChI InChI=1S/C25H20ClNO3/c1-17-10-12-23(27(17)21-9-5-8-19(14-21)25(28)29)22-15-20(26)11-13-24(22)30-16-18-6-3-2-4-7-18/h2-15H,16H2,1H3,(H,28,29) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50423558
(CHEMBL255009)Show InChI InChI=1S/C15H16ClNO3S/c1-9(2)7-20-13-4-3-11(16)5-10(13)6-14-17-12(8-21-14)15(18)19/h3-5,8-9H,6-7H2,1-2H3,(H,18,19)/p-1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412239
(CHEMBL492237)Show SMILES CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 Show InChI InChI=1S/C24H29ClN4O2/c1-16(2)15-31-23-10-7-20(25)12-19(23)14-29-17(3)11-22(28-29)24(30)27-21-8-5-18(6-9-21)13-26-4/h5-12,16,26H,13-15H2,1-4H3,(H,27,30) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412238
(CHEMBL523158)Show SMILES CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 Show InChI InChI=1S/C25H31ClN4O2/c1-5-27-14-19-6-9-22(10-7-19)28-25(31)23-12-18(4)30(29-23)15-20-13-21(26)8-11-24(20)32-16-17(2)3/h6-13,17,27H,5,14-16H2,1-4H3,(H,28,31) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412234
(CHEMBL523679)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(cc1C)C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C27H33ClN4O3/c1-19(2)18-35-26-9-6-23(28)15-22(26)17-32-20(3)14-25(30-32)27(33)29-24-7-4-21(5-8-24)16-31-10-12-34-13-11-31/h4-9,14-15,19H,10-13,16-18H2,1-3H3,(H,29,33) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412229
(CHEMBL480950)Show SMILES CN(C)Cc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 Show InChI InChI=1S/C28H29ClN4O2/c1-20-15-26(28(34)30-25-12-9-21(10-13-25)17-32(2)3)31-33(20)18-23-16-24(29)11-14-27(23)35-19-22-7-5-4-6-8-22/h4-16H,17-19H2,1-3H3,(H,30,34) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50290085
((2S,3R)-N*4*-((R)-2,2-Dimethyl-1-methylcarbamoyl-p...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CN1C(=O)c2ccccc2C1=O)C(=O)NO)C(C)(C)C Show InChI InChI=1S/C24H34N4O6/c1-13(2)11-16(19(29)26-18(21(31)25-6)24(3,4)5)17(20(30)27-34)12-28-22(32)14-9-7-8-10-15(14)23(28)33/h7-10,13,16-18,34H,11-12H2,1-6H3,(H,25,31)(H,26,29)(H,27,30)/t16-,17-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human stromelysin-1, MMP-3 |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50290086
((R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)-pro...)Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C Show InChI InChI=1S/C15H29N3O4/c1-9(2)7-10(8-11(19)18-22)13(20)17-12(14(21)16-6)15(3,4)5/h9-10,12,22H,7-8H2,1-6H3,(H,16,21)(H,17,20)(H,18,19)/t10-,12+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human gelatinase B, MMP9 |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412224
(CHEMBL479591)Show SMILES Cc1cc(nn1Cc1cc(Cl)ccc1OCc1ccccc1)C(=O)Nc1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C30H31ClN4O3/c1-22-17-28(30(36)32-27-10-7-23(8-11-27)19-34-13-15-37-16-14-34)33-35(22)20-25-18-26(31)9-12-29(25)38-21-24-5-3-2-4-6-24/h2-12,17-18H,13-16,19-21H2,1H3,(H,32,36) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412226
(CHEMBL404525)Show InChI InChI=1S/C19H17ClN2O3/c1-13-9-17(19(23)24)21-22(13)11-15-10-16(20)7-8-18(15)25-12-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,23,24)/p-1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50423571
(CHEMBL270208)Show InChI InChI=1S/C16H19ClN2O3/c1-10(2)9-22-15-5-4-13(17)7-12(15)8-19-11(3)6-14(18-19)16(20)21/h4-7,10H,8-9H2,1-3H3,(H,20,21)/p-1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50423573
(CHEMBL407175)Show InChI InChI=1S/C20H17ClO4/c1-13-9-19(20(22)23)25-18(13)11-15-10-16(21)7-8-17(15)24-12-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,22,23)/p-1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase/Collagenase 3/Interstitial collagenase/Matrix metalloproteinase-9/Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50290087
((2S,3R)-5-Methyl-3-(piperidine-1-carbonyl)-2-(3,4,...)Show SMILES CC(C)C[C@H]([C@@H](CN1C(=O)N(C)C(C)(C)C1=O)C(=O)NO)C(=O)N1CCCCC1 Show InChI InChI=1S/C20H34N4O5/c1-13(2)11-14(17(26)23-9-7-6-8-10-23)15(16(25)21-29)12-24-18(27)20(3,4)22(5)19(24)28/h13-15,29H,6-12H2,1-5H3,(H,21,25)/t14-,15-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors) |
Bioorg Med Chem Lett 7: 2299-2302 (1997)
Article DOI: 10.1016/S0960-894X(97)00416-2
BindingDB Entry DOI: 10.7270/Q26T0MM8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412226
(CHEMBL404525)Show InChI InChI=1S/C19H17ClN2O3/c1-13-9-17(19(23)24)21-22(13)11-15-10-16(20)7-8-18(15)25-12-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,23,24)/p-1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from EP1 receptor |
Bioorg Med Chem Lett 18: 1592-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.071
BindingDB Entry DOI: 10.7270/Q2N58NNN |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412227
(CHEMBL480181)Show SMILES Cc1cc(nn1Cc1cc(Cl)ccc1OCc1ccccc1)C(=O)Nc1ccc(CN2CCCCC2)cc1 Show InChI InChI=1S/C31H33ClN4O2/c1-23-18-29(31(37)33-28-13-10-24(11-14-28)20-35-16-6-3-7-17-35)34-36(23)21-26-19-27(32)12-15-30(26)38-22-25-8-4-2-5-9-25/h2,4-5,8-15,18-19H,3,6-7,16-17,20-22H2,1H3,(H,33,37) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412228
(CHEMBL479989)Show SMILES Cc1cc(nn1Cc1cc(Cl)ccc1OCc1ccccc1)C(=O)Nc1ccc(CN2CCCC2)cc1 Show InChI InChI=1S/C30H31ClN4O2/c1-22-17-28(30(36)32-27-12-9-23(10-13-27)19-34-15-5-6-16-34)33-35(22)20-25-18-26(31)11-14-29(25)37-21-24-7-3-2-4-8-24/h2-4,7-14,17-18H,5-6,15-16,19-21H2,1H3,(H,32,36) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412230
(CHEMBL480790)Show SMILES CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 Show InChI InChI=1S/C28H29ClN4O2/c1-3-30-17-21-9-12-25(13-10-21)31-28(34)26-15-20(2)33(32-26)18-23-16-24(29)11-14-27(23)35-19-22-7-5-4-6-8-22/h4-16,30H,3,17-19H2,1-2H3,(H,31,34) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412225
(CHEMBL480789)Show SMILES CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 Show InChI InChI=1S/C27H27ClN4O2/c1-19-14-25(27(33)30-24-11-8-20(9-12-24)16-29-2)31-32(19)17-22-15-23(28)10-13-26(22)34-18-21-6-4-3-5-7-21/h3-15,29H,16-18H2,1-2H3,(H,30,33) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50412216
(CHEMBL447709)Show SMILES CC(C)COc1ccc(Cl)cc1Cn1nc(NC(=O)c2ccc(CO)cc2)cc1C Show InChI InChI=1S/C23H26ClN3O3/c1-15(2)14-30-21-9-8-20(24)11-19(21)12-27-16(3)10-22(26-27)25-23(29)18-6-4-17(13-28)5-7-18/h4-11,15,28H,12-14H2,1-3H3,(H,25,26,29) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Displacement of [H3PGE2 from human EP1 receptor expressed in CHOK1 cells |
Bioorg Med Chem Lett 18: 4027-32 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.118
BindingDB Entry DOI: 10.7270/Q2NC62F7 |
More data for this
Ligand-Target Pair | |
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