| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50412494 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_557000 (CHEMBL960691) |
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| Ki | 15.85±n/a nM |
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| Citation |  Smits, RA; de Esch, IJ; Zuiderveld, OP; Broeker, J; Sansuk, K; Guaita, E; Coruzzi, G; Adami, M; Haaksma, E; Leurs, R Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. J Med Chem51:7855-65 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | HH4R | HRH4_RAT | Hrh4 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44045.07 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Cell pellets from SK-N-MC cells transfected with rat H4 receptor were used in binding assay. |
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| Residue: | 391 |
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| Sequence: | MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAIS
DFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAV
RYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAIT
AFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSL
PGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRG
RKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLY
PLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
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| BDBM50412494 |
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| n/a |
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| Name | BDBM50412494 |
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| Synonyms: | CHEMBL452847 | VUF-10497 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20ClN5S |
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| Mol. Mass. | 373.903 |
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| SMILES | CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1 |
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| Structure | 
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