Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM50397292 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_556997 (CHEMBL958183) |
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Ki | 97.72±n/a nM |
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Citation | Smits, RA; de Esch, IJ; Zuiderveld, OP; Broeker, J; Sansuk, K; Guaita, E; Coruzzi, G; Adami, M; Haaksma, E; Leurs, R Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. J Med Chem51:7855-65 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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BDBM50397292 |
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n/a |
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Name | BDBM50397292 |
Synonyms: | CHEMBL454890 | VUF-10499 |
Type | Small organic molecule |
Emp. Form. | C18H20ClN5O |
Mol. Mass. | 357.837 |
SMILES | CN1CCN(CC1)c1nc(NCc2ccoc2)c2cc(Cl)ccc2n1 |
Structure |
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