| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H4 receptor |
|---|
| Ligand | BDBM50415767 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_614999 (CHEMBL1116876) |
|---|
| Ki | 7.08±n/a nM |
|---|
| Citation |  Koenig, JR; Liu, H; Drizin, I; Witte, DG; Carr, TL; Manelli, AM; Milicic, I; Strakhova, MI; Miller, TR; Esbenshade, TA; Brioni, JD; Cowart, M Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring. Bioorg Med Chem Lett20:1900-4 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H4 receptor |
|---|
| Name: | Histamine H4 receptor |
|---|
| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 44517.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
|---|
| Residue: | 390 |
|---|
| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
|
|
|
|---|
| BDBM50415767 |
|---|
| n/a |
|---|
| Name | BDBM50415767 |
|---|
| Synonyms: | CHEMBL1077276 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H29N5 |
|---|
| Mol. Mass. | 363.4992 |
|---|
| SMILES | Nc1nc2C(CCCCc2c(n1)N1CC2CCCNC2C1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
