Reaction Details |
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Target | Histamine H4 receptor |
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Ligand | BDBM50415767 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_615000 (CHEMBL1116877) |
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Ki | 2.69±n/a nM |
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Citation | Koenig, JR; Liu, H; Drizin, I; Witte, DG; Carr, TL; Manelli, AM; Milicic, I; Strakhova, MI; Miller, TR; Esbenshade, TA; Brioni, JD; Cowart, M Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring. Bioorg Med Chem Lett20:1900-4 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H4 receptor |
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Name: | Histamine H4 receptor |
Synonyms: | HH4R | HRH4_RAT | Hrh4 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44045.07 |
Organism: | Rattus norvegicus (rat) |
Description: | Cell pellets from SK-N-MC cells transfected with rat H4 receptor were used in binding assay. |
Residue: | 391 |
Sequence: | MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAIS
DFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAV
RYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAIT
AFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSL
PGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRG
RKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLY
PLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
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BDBM50415767 |
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n/a |
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Name | BDBM50415767 |
Synonyms: | CHEMBL1077276 |
Type | Small organic molecule |
Emp. Form. | C22H29N5 |
Mol. Mass. | 363.4992 |
SMILES | Nc1nc2C(CCCCc2c(n1)N1CC2CCCNC2C1)c1ccccc1 |
Structure |
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