| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50415768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_614998 (CHEMBL1116875) |
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| Ki | 104.71±n/a nM |
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| Citation |  Koenig, JR; Liu, H; Drizin, I; Witte, DG; Carr, TL; Manelli, AM; Milicic, I; Strakhova, MI; Miller, TR; Esbenshade, TA; Brioni, JD; Cowart, M Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring. Bioorg Med Chem Lett20:1900-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50415768 |
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| n/a |
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| Name | BDBM50415768 |
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| Synonyms: | CHEMBL1089040 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H27N5 |
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| Mol. Mass. | 337.4619 |
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| SMILES | CN[C@@H]1CCN(C1)c1nc(N)nc2CC(CCCc12)c1ccccc1 |r| |
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| Structure | 
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