Reaction Details | |||
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Target | Neuropeptide Y receptor type 5 | ||
Ligand | BDBM50417046 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_664979 (CHEMBL1259936) | ||
Ki | 0.1±n/a nM | ||
Citation | Leslie, CP; Bentley, J; Biagetti, M; Contini, S; Di Fabio, R; Donati, D; Genski, T; Guery, S; Mazzali, A; Merlo, G; Pizzi, DA; Sacco, F; Seri, C; Tessari, M; Zonzini, L; Caberlotto, L Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists. Bioorg Med Chem Lett20:6103-7 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuropeptide Y receptor type 5 | |||
Name: | Neuropeptide Y receptor type 5 | ||
Synonyms: | NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor | ||
Type: | Enzyme | ||
Mol. Mass.: | 50746.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15761 | ||
Residue: | 445 | ||
Sequence: |
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BDBM50417046 | |||
n/a | |||
Name | BDBM50417046 | ||
Synonyms: | CHEMBL1258453 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H23FN6O2 | ||
Mol. Mass. | 422.4554 | ||
SMILES | Fc1ccccc1-n1cc(NC[C@H]2CC[C@@]3(CN(C(=O)O3)c3cccnn3)CC2)cn1 |r,wU:12.12,wD:15.21,(16.1,-16.72,;14.7,-16.07,;13.45,-16.97,;12.04,-16.31,;11.91,-14.78,;13.16,-13.9,;14.56,-14.55,;15.81,-13.67,;17.27,-14.16,;18.2,-12.92,;19.74,-12.95,;20.49,-14.3,;22.03,-14.32,;22.82,-13,;24.36,-13.02,;25.1,-14.37,;26.24,-13.33,;27.58,-14.11,;27.26,-15.62,;28.28,-16.76,;25.73,-15.78,;28.99,-13.49,;30.23,-14.4,;31.63,-13.78,;31.8,-12.24,;30.55,-11.33,;29.15,-11.97,;24.31,-15.69,;22.78,-15.66,;17.31,-11.67,;15.84,-12.13,)| | ||
Structure |