| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V1a receptor |
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| Ligand | BDBM50418370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_746763 (CHEMBL1776932) |
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| Ki | >1000±n/a nM |
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| Citation |  Napier, S; Wishart, G; Arbuckle, W; Baker, J; Barn, D; Bingham, M; Brown, A; Byford, A; Claxton, C; Craighead, M; Buchanan, K; Fielding, L; Gibson, L; Goodwin, R; Goutcher, S; Irving, N; MacSweeney, C; Milne, R; Mort, C; Presland, J; Sloan, H; Thomson, F; Turnbull, Z; Young, T The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists. Bioorg Med Chem Lett21:3163-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V1a receptor |
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| Name: | Vasopressin V1a receptor |
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| Synonyms: | Avpr1a | V1AR_RAT | VASOPRESSIN V1A | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47674.81 |
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| Organism: | RAT |
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| Description: | VASOPRESSIN V1A AVPR1A RAT::P30560 |
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| Residue: | 424 |
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| Sequence: | MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAV
IFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGP
DWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFI
LSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGF
ICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTF
VIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGH
LLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFI
PVST
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| BDBM50418370 |
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| n/a |
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| Name | BDBM50418370 |
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| Synonyms: | CHEMBL1774018 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29ClFN3O2 |
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| Mol. Mass. | 457.968 |
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| SMILES | CN1[C@H]2CC[C@@H]1C[C@@H](C2)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccc(F)cc1 |r,TLB:0:1:4.3:7.6.8| |
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| Structure | 
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