Reaction Details |
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Target | Mitogen-activated protein kinase 11 |
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Ligand | BDBM50418610 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_749732 (CHEMBL1787753) |
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Ki | 25.12±n/a nM |
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Citation | Aston, NM; Bamborough, P; Buckton, JB; Edwards, CD; Holmes, DS; Jones, KL; Patel, VK; Smee, PA; Somers, DO; Vitulli, G; Walker, AL p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. J Med Chem52:6257-69 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 11 |
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Name: | Mitogen-activated protein kinase 11 |
Synonyms: | MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41351.73 |
Organism: | Homo sapiens (Human) |
Description: | gi_20128774 |
Residue: | 364 |
Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
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BDBM50418610 |
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n/a |
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Name | BDBM50418610 |
Synonyms: | GW-856553 | GW856553X | LOSMAPIMOD | US10550073, Comparative example |
Type | Small organic molecule |
Emp. Form. | C22H26FN3O2 |
Mol. Mass. | 383.4591 |
SMILES | Cc1c(F)cc(cc1-c1ccc(cn1)C(=O)NCC(C)(C)C)C(=O)NC1CC1 |
Structure |
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