Ki Summary

Reaction Details

Report a problem with these data

Target

Cholecystokinin receptor type A

Ligand

BDBM50418880

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_757822 (CHEMBL1809766)

1580±n/a nM

Citation

Roberts, K; Ursini, A; Barnaby, R; Cassarà, PG; Corsi, M; Curotto, G; Donati, D; Feriani, A; Finizia, G; Marchioro, C; Niccolai, D; Oliosi, B; Polinelli, S; Ratti, E; Reggiani, A; Tedesco, G; Tranquillini, ME; Trist, DG; van Amsterdam, FT Synthesis and structure-activity relationship of new 1,5-dialkyl-1,5-benzodiazepines as cholecystokinin-2 receptor antagonists. Bioorg Med Chem19:4257-73 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cholecystokinin receptor type A

Name:

Cholecystokinin receptor type A

Synonyms:

CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49676.37

Organism:

RAT

Description:

Cholecystokinin central 0 RAT::P30551

Residue:

444

Sequence:

MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQI
LLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK
DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAAT
WCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVM
VVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQL
SSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAE
KHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEE
DGRTIRALLSRYSYSHMSTSAPPP

BDBM50418880

n/a

Name

BDBM50418880

Synonyms:

CHEMBL1808416

Type

Small organic molecule

Emp. Form.

C33H41N5O4

Mol. Mass.

571.7097

SMILES

O=C(NC1C(=O)N(CCN2CCOCC2)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O)Nc1ccccc1 |TLB:32:23:30:27.26.28,22:23:26:30.29.28,THB:32:27:30:23.31.24,31:29:26:32.23.24,31:23:26:30.29.28|

Structure