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TargetCoagulation factor XIII
LigandBDBM50420459
Substrate/Competitorn/a
Meas. Tech.ChEMBL_841034
IC50 180±n/a nM
Citation Prime MEAndersen OABarker JJBrooks MACheng RKToogood-Johnson ICourtney SMBrookfield FAYarnold CJMarston RWJohnson PDJohnsen SFPalfrey JJVaidya DErfan SIchihara OFelicetti BPalan SPedret-Dunn ASchaertl SSternberger IEbneth AScheel AWinkler DToledo-Sherman LBeconi MMacdonald DMuñoz-Sanjuan IDominguez CWityak J Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem 55:1021-46 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor XIII
Name:Coagulation factor XIII
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:83261.29
Organism:Homo sapiens (Human)
Description:ChEMBL_1475048
Residue:732
Sequence:
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
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BDBM50420459
n/a
NameBDBM50420459
Synonyms:CHEMBL2086528
TypeSmall organic molecule
Emp. Form.C24H31N3O4S
Mol. Mass.457.586
SMILESC=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:31:22:29:25.26.27,20:22:29:25.26.27,THB:31:26:23.22.30:29,27:26:23:30.28.29,27:28:23:25.31.26|
Structure
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