Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50420907 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
IC50 | 24±n/a nM | ||
Citation | Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50420907 | |||
n/a | |||
Name | BDBM50420907 | ||
Synonyms: | CHEMBL2087553 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H33N3O | ||
Mol. Mass. | 403.5597 | ||
SMILES | CCc1nn2c(cccc2c1N(CC1CC1)CC1CC1)-c1c(C)cc(C)cc1OC |(-4.21,1.75,;-3.44,.42,;-1.9,.42,;-.99,-.82,;.48,-.34,;1.81,-1.1,;3.14,-.32,;3.14,1.22,;1.8,1.98,;.47,1.2,;-1,1.67,;-1.48,3.14,;-2.99,3.45,;-3.39,4.94,;-3,6.43,;-4.49,6.02,;-.45,4.29,;-.86,5.77,;-.47,7.26,;-1.95,6.86,;1.82,-2.64,;3.16,-3.4,;4.49,-2.63,;3.16,-4.94,;1.83,-5.72,;1.84,-7.26,;.5,-4.96,;.49,-3.42,;-.85,-2.65,;-2.18,-3.43,)| | ||
Structure |