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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420911 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 41±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420911 | |||
| n/a | |||
| Name | BDBM50420911 | ||
| Synonyms: | CHEMBL2087557 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33N3O2 | ||
| Mol. Mass. | 407.5484 | ||
| SMILES | CCc1nn2c(cccc2c1N(CCOC)CC1CC1)-c1c(C)cc(C)cc1OC |(-4.74,1.26,;-3.99,-.08,;-2.45,-.09,;-1.55,-1.35,;-.08,-.88,;1.25,-1.66,;2.59,-.9,;2.6,.64,;1.27,1.42,;-.07,.66,;-1.53,1.15,;-1.99,2.61,;-.96,3.75,;-1.5,5.19,;-.52,6.38,;-1.06,7.82,;-3.5,2.95,;-4.04,4.39,;-5.23,5.37,;-3.79,5.91,;1.23,-3.2,;-.11,-3.96,;-1.43,-3.18,;-.12,-5.5,;1.21,-6.28,;1.2,-7.82,;2.55,-5.52,;2.56,-3.98,;3.9,-3.22,;5.23,-4,)| | ||
| Structure | 
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