Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50420913 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
IC50 | 38±n/a nM | ||
Citation | Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
| ||
BDBM50420913 | |||
n/a | |||
Name | BDBM50420913 | ||
Synonyms: | CHEMBL2087559 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H35N3O2 | ||
Mol. Mass. | 433.5857 | ||
SMILES | CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOC1)-c1c(C)cc(C)cc1OC |(-4.51,-1.39,;-3.74,-.05,;-2.2,-.05,;-1.3,-1.28,;.17,-.81,;1.5,-1.58,;2.83,-.81,;2.83,.73,;1.5,1.5,;.17,.73,;-1.3,1.21,;-1.78,2.67,;-3.5,2.95,;-4.3,4.26,;-5.81,4.72,;-4.41,5.79,;-.69,3.76,;-1.09,5.25,;-2.52,5.8,;-2.44,7.34,;-.96,7.74,;-.12,6.44,;1.51,-3.12,;.17,-3.89,;-1.16,-3.12,;.17,-5.43,;1.51,-6.2,;1.51,-7.74,;2.84,-5.42,;2.85,-3.89,;4.18,-3.12,;5.51,-3.89,)| | ||
Structure |