Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50420914 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
IC50 | 34±n/a nM | ||
Citation | Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50420914 | |||
n/a | |||
Name | BDBM50420914 | ||
Synonyms: | CHEMBL2087560 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H35N3O2 | ||
Mol. Mass. | 433.5857 | ||
SMILES | CCc1nn2c(cccc2c1N(CC1CC1)CC1CCCO1)-c1c(C)cc(C)cc1OC |(-4.19,-1.4,;-3.42,-.06,;-1.88,-.05,;-.97,-1.29,;.49,-.81,;1.83,-1.57,;3.16,-.8,;3.15,.74,;1.81,1.51,;.48,.73,;-.98,1.2,;-1.47,2.66,;-2.98,2.97,;-4.3,2.19,;-5.07,.86,;-5.84,2.18,;-.44,3.81,;-1,5.24,;-2.49,5.64,;-2.58,7.17,;-1.15,7.73,;-.17,6.54,;1.84,-3.11,;.51,-3.89,;-.83,-3.13,;.52,-5.43,;1.86,-6.19,;1.86,-7.73,;3.19,-5.42,;3.18,-3.88,;4.51,-3.1,;5.84,-3.86,)| | ||
Structure |