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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420917 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 40±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420917 | |||
| n/a | |||
| Name | BDBM50420917 | ||
| Synonyms: | CHEMBL2087563 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H37N3O3 | ||
| Mol. Mass. | 463.6117 | ||
| SMILES | CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(C)cc(OC)cc1OC |(-3.66,-1.15,;-2.89,.19,;-1.35,.17,;-.46,-1.08,;1.01,-.62,;2.34,-1.4,;3.68,-.64,;3.69,.9,;2.37,1.68,;1.03,.92,;-.44,1.41,;-.9,2.88,;-2.4,3.21,;-3.5,2.13,;-4.99,1.75,;-3.91,.65,;.14,4.01,;-.4,5.46,;.58,6.65,;.05,8.09,;-1.47,8.34,;-2.45,7.15,;-1.91,5.71,;2.32,-2.94,;3.65,-3.72,;4.99,-2.97,;3.64,-5.26,;2.3,-6.02,;2.28,-7.56,;3.61,-8.34,;.97,-5.24,;.98,-3.7,;-.34,-2.92,;-1.68,-3.67,)| | ||
| Structure | 
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