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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420921 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 120±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420921 | |||
| n/a | |||
| Name | BDBM50420921 | ||
| Synonyms: | CHEMBL2087568 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H39N3O4 | ||
| Mol. Mass. | 493.6377 | ||
| SMILES | CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(COC)cc(OC)cc1OC |(-5.15,1.89,;-4.41,.54,;-2.87,.51,;-1.99,-.75,;-.51,-.3,;.8,-1.1,;2.15,-.35,;2.18,1.19,;.86,1.98,;-.49,1.24,;-1.94,1.74,;-2.39,3.22,;-1.34,4.34,;.18,4.07,;1.63,4.6,;1.36,3.08,;-3.89,3.57,;-4.26,5.06,;-5.74,5.49,;-6.11,6.98,;-5,8.05,;-3.52,7.62,;-3.15,6.13,;.77,-2.64,;2.09,-3.43,;3.44,-2.69,;4.76,-3.48,;6.11,-2.74,;2.06,-4.97,;.72,-5.71,;.69,-7.25,;2.01,-8.05,;-.6,-4.92,;-.57,-3.38,;-1.89,-2.58,;-3.24,-3.33,)| | ||
| Structure | 
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