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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420922 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 49±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420922 | |||
| n/a | |||
| Name | BDBM50420922 | ||
| Synonyms: | CHEMBL2087569 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H41N3O4 | ||
| Mol. Mass. | 507.6642 | ||
| SMILES | CCOCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(CC)nn12 |(4.24,-9.12,;2.9,-8.36,;2.9,-6.82,;1.56,-6.05,;1.56,-4.51,;2.89,-3.74,;2.88,-2.2,;4.21,-1.42,;5.55,-2.19,;1.55,-1.43,;.22,-2.21,;-1.12,-1.44,;-2.45,-2.21,;.22,-3.75,;1.54,.11,;2.87,.88,;2.87,2.42,;1.53,3.19,;.2,2.41,;-1.27,2.89,;-1.75,4.35,;-.72,5.5,;.8,5.26,;2.24,5.82,;2,4.3,;-3.25,4.66,;-3.66,6.15,;-5.15,6.54,;-5.55,8.03,;-4.47,9.12,;-2.98,8.73,;-2.57,7.24,;-2.17,1.64,;-3.71,1.63,;-4.48,2.96,;-1.26,.39,;.21,.87,)| | ||
| Structure | 
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